DegronMD

Uniprot ID: P51828

Source protein: Adenylate cyclase type 7

Source gene: ADCY7

Class: DEG_Kelch_Keap1_1

Location: 505:510

E3 ligase: KEAP1

DEGRON score: 0.988

ASA_SCORE: 71.1167

COIL: 0.8085

CONS_SCORE: 0.3828

DSS_SCORE: 0.652

HELIX: 0.0912

FCONS_SCORE: 1.0387

RIG_SCORE: 0.5533

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R517Q	TCGA-EE-A29D	SKCM	TCGA	SVSSGE	DEG_Kelch_Keap1_1	0.1389
p.R517Q	DO38123	SKCM	ICGC	SVSSGE	DEG_Kelch_Keap1_1	0.1389
p.P519H	TCGA-EE-A2MM	SKCM	TCGA	SVSSGE	DEG_Kelch_Keap1_1	0.0833
p.P519H	DO37770	SKCM	ICGC	SVSSGE	DEG_Kelch_Keap1_1	0.0833
p.R517W	TCGA-FI-A2D5	UCEC	TCGA	SVSSGE	DEG_Kelch_Keap1_1	0.1389
p.R517W	DO41331	UCEC	ICGC	SVSSGE	DEG_Kelch_Keap1_1	0.1389
p.H502Y	TCGA-FR-A8YC	SKCM	TCGA	SVSSGE	DEG_Kelch_Keap1_1	0.25
p.H502Y	TCGA-W3-AA1V	SKCM	TCGA	SVSSGE	DEG_Kelch_Keap1_1	0.25
p.H502Y	DO50301	SKCM	ICGC	SVSSGE	DEG_Kelch_Keap1_1	0.25
p.H502Y	DO51276	SKCM	ICGC	SVSSGE	DEG_Kelch_Keap1_1	0.25
p.V506M	TCGA-IB-7651	PAAD	TCGA	SVSSGE	DEG_Kelch_Keap1_1	0.6097
p.V506M	DO46657	PAAD	ICGC	SVSSGE	DEG_Kelch_Keap1_1	0.6097
p.V506M	DO35210	PACA	ICGC	SVSSGE	DEG_Kelch_Keap1_1	0.6097
p.V506M	SIDM01175	Other Sarcomas	GDSC	SVSSGE	DEG_Kelch_Keap1_1	0.6097
p.V506M	SW684	soft_tissue	COSMIC	SVSSGE	DEG_Kelch_Keap1_1	0.6097
p.R503C	DO50555	BOCA	ICGC	SVSSGE	DEG_Kelch_Keap1_1	0.2778
p.V513I	DO230336	COCA	ICGC	SVSSGE	DEG_Kelch_Keap1_1	0.25
p.S505G	DO233621	GACA	ICGC	SVSSGE	DEG_Kelch_Keap1_1	0.8104
p.E504D	DO229024	LICA	ICGC	SVSSGE	DEG_Kelch_Keap1_1	0.3056
p.S508C	DO222402	MELA	ICGC	SVSSGE	DEG_Kelch_Keap1_1	0.7541
p.G516R	SIDM00660	Colorectal Carcinoma	GDSC	SVSSGE	DEG_Kelch_Keap1_1	0.1667
p.R495W	SIDM00783	Colorectal Carcinoma	GDSC	SVSSGE	DEG_Kelch_Keap1_1	0.0556
p.R495W	ACH-000971	Colon/Colorectal Cancer	CCLE	SVSSGE	DEG_Kelch_Keap1_1	0.0556
p.R495W	HCT-116	large_intestine	COSMIC	SVSSGE	DEG_Kelch_Keap1_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons