DegronMD

Uniprot ID: O14594

Source protein: Neurocan core protein

Source gene: NCAN

Class: DEG_SCF_FBW7_1

Location: 869:875

E3 ligase: FBXW7

DEGRON score: 0.8744

ASA_SCORE: 78.7143

COIL: 0.7629

CONS_SCORE: 0.4179

DSS_SCORE: 0.4676

HELIX: 0.0217

FCONS_SCORE: 0.901

RIG_SCORE: 0.814

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V863L	TCGA-17-Z031	LUAD	TCGA	IVTPLTT	DEG_SCF_FBW7_1	0.1667
p.V863L	TCGA-60-2715	LUSC	TCGA	IVTPLTT	DEG_SCF_FBW7_1	0.1667
p.T871M	TCGA-25-1320	OV	TCGA	IVTPLTT	DEG_SCF_FBW7_1	0.7423
p.Q862L	TCGA-56-8082	LUSC	TCGA	IVTPLTT	DEG_SCF_FBW7_1	0.1389
p.V884L	TCGA-B6-A0RS	BRCA	TCGA	IVTPLTT	DEG_SCF_FBW7_1	0.0833
p.T874M	TCGA-BR-6566	STAD	TCGA	IVTPLTT	DEG_SCF_FBW7_1	0.6312
p.P885S	TCGA-D3-A2JL	SKCM	TCGA	IVTPLTT	DEG_SCF_FBW7_1	0.0556
p.D866N	TCGA-FD-A3NA	BLCA	TCGA	IVTPLTT	DEG_SCF_FBW7_1	0.25
p.T875S	SIDM01121	Small Cell Lung Carcinoma	GDSC	IVTPLTT	DEG_SCF_FBW7_1	0.6005
p.T875S	SIDM00793	Burkitt's Lymphoma	GDSC	IVTPLTT	DEG_SCF_FBW7_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14594	Neurocan core protein	DEG_SCF_FBW7_1	869:875	IVTPLTT	FBXW7	0.8744	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons