DegronMD

Uniprot ID: O14594

Source protein: Neurocan core protein

Source gene: NCAN

Class: DEG_SCF_FBW7_2

Location: 808:815

E3 ligase: FBXW7

DEGRON score: 0.919

ASA_SCORE: 101.0875

COIL: 0.9299

CONS_SCORE: 0.4717

DSS_SCORE: 0.4131

HELIX: 0.0181

FCONS_SCORE: 0.9053

RIG_SCORE: 0.7533

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P802S	TCGA-25-2398	OV	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	0.1667
p.P816T	TCGA-A5-A0G1	UCEC	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	0.3056
p.D821Y	TCGA-AX-A2HC	UCEC	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	0.1667
p.T825A	TCGA-BR-4363	STAD	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	0.0556
p.D821N	TCGA-CK-4951	COAD	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	0.1667
p.V804F	TCGA-D1-A103	UCEC	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	0.2222
p.N813H	TCGA-E6-A1LX	UCEC	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	0.6312
p.L814V	TCGA-EO-A3B0	UCEC	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	0.5654
p.E815K	TCGA-ER-A19Q	SKCM	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	0.7022
p.D821G	SIDM00581	Glioblastoma	GDSC	PKVTPNLE	DEG_SCF_FBW7_2	0.1667
p.D821G	ACH-000738	Brain Cancer	CCLE	PKVTPNLE	DEG_SCF_FBW7_2	0.1667
p.D821G	GB-1	central_nervous_system	COSMIC	PKVTPNLE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14594	Neurocan core protein	DEG_SCF_FBW7_2	808:815	PKVTPNLE	FBXW7	0.919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons