DegronMD

Uniprot ID: O14594

Source protein: Neurocan core protein

Source gene: NCAN

Class: DEG_SPOP_SBC_1

Location: 854:858

E3 ligase: SPOP

DEGRON score: 0.7876

ASA_SCORE: 86.22

COIL: 0.7738

CONS_SCORE: 0.3367

DSS_SCORE: 0.5519

HELIX: 0.1306

FCONS_SCORE: 0.745

RIG_SCORE: 0.7289

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q849K	TCGA-05-4396	LUAD	TCGA	AESTT	DEG_SPOP_SBC_1	0.1944
p.V863L	TCGA-17-Z031	LUAD	TCGA	AESTT	DEG_SPOP_SBC_1	0.1944
p.V863L	TCGA-60-2715	LUSC	TCGA	AESTT	DEG_SPOP_SBC_1	0.1944
p.Q862L	TCGA-56-8082	LUSC	TCGA	AESTT	DEG_SPOP_SBC_1	0.2222
p.D866N	TCGA-FD-A3NA	BLCA	TCGA	AESTT	DEG_SPOP_SBC_1	0.1111
p.Q849H	SIDM01770	Gastric Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.1944
p.Q849H	ACH-000908	Gastric Cancer	CCLE	AESTT	DEG_SPOP_SBC_1	0.1944
p.E855K	SIDM01368	Gastric Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14594	Neurocan core protein	DEG_SPOP_SBC_1	854:858	AESTT	SPOP	0.7876	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6335:6339	AESTT	SPOP	0.5654	More...
Q99504	Eyes absent homolog 3	DEG_SPOP_SBC_1	227:231	AESTT	SPOP	0.9997	More...
Q99698	Lysosomal-trafficking regulator	DEG_SPOP_SBC_1	1487:1491	AESTT	SPOP	0.7185	More...
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_SPOP_SBC_1	178:182	AESTT	SPOP	0.9262	More...
Q9C093	Sperm flagellar protein 2	DEG_SPOP_SBC_1	548:552	AESTT	SPOP	0.8268	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4852:4856	AESTT	SPOP	0.6629	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons