DegronMD

Uniprot ID: Q99698

Source protein: Lysosomal-trafficking regulator

Source gene: LYST

Class: DEG_SPOP_SBC_1

Location: 1487:1491

E3 ligase: SPOP

DEGRON score: 0.7185

ASA_SCORE: 79.14

COIL: 0.7556

CONS_SCORE: 0.2531

DSS_SCORE: 0.2578

HELIX: 0.1658

FCONS_SCORE: 0.7606

RIG_SCORE: 0.7724

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1498N	TCGA-AX-A2HC	UCEC	TCGA	AESTT	DEG_SPOP_SBC_1	0.25
p.K1498N	TCGA-B5-A1MR	UCEC	TCGA	AESTT	DEG_SPOP_SBC_1	0.25
p.K1498N	DO7801	COAD	ICGC	AESTT	DEG_SPOP_SBC_1	0.25
p.K1498N	DO41758	UCEC	ICGC	AESTT	DEG_SPOP_SBC_1	0.25
p.K1498N	DO41572	UCEC	ICGC	AESTT	DEG_SPOP_SBC_1	0.25
p.K1498M	TCGA-EM-A3SY	THCA	TCGA	AESTT	DEG_SPOP_SBC_1	0.25
p.K1498M	DO48063	THCA	ICGC	AESTT	DEG_SPOP_SBC_1	0.25
p.R1500I	DO7801	COAD	ICGC	AESTT	DEG_SPOP_SBC_1	0.0833
p.H1485N	DO228976	LICA	ICGC	AESTT	DEG_SPOP_SBC_1	0.2778
p.H1485N	DO220883	MELA	ICGC	AESTT	DEG_SPOP_SBC_1	0.2778
p.A1487D	DO229028	LICA	ICGC	AESTT	DEG_SPOP_SBC_1	0.7793
p.E1486D	DO232761	PBCA	ICGC	AESTT	DEG_SPOP_SBC_1	0.3056
p.V1481A	SIDM00217	Colorectal Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.1667
p.V1481A	ACH-000999	Colon/Colorectal Cancer	CCLE	AESTT	DEG_SPOP_SBC_1	0.1667
p.V1481A	SNU-1040	large_intestine	COSMIC	AESTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14594	Neurocan core protein	DEG_SPOP_SBC_1	854:858	AESTT	SPOP	0.7876	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6335:6339	AESTT	SPOP	0.5654	More...
Q99504	Eyes absent homolog 3	DEG_SPOP_SBC_1	227:231	AESTT	SPOP	0.9997	More...
Q99698	Lysosomal-trafficking regulator	DEG_SPOP_SBC_1	1487:1491	AESTT	SPOP	0.7185	More...
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_SPOP_SBC_1	178:182	AESTT	SPOP	0.9262	More...
Q9C093	Sperm flagellar protein 2	DEG_SPOP_SBC_1	548:552	AESTT	SPOP	0.8268	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4852:4856	AESTT	SPOP	0.6629	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons