DegronMD

Uniprot ID: Q9BYW2

Source protein: Histone-lysine N-methyltransferase SETD2

Source gene: SETD2

Class: DEG_SPOP_SBC_1

Location: 178:182

E3 ligase: SPOP

DEGRON score: 0.9262

ASA_SCORE: 93.78

COIL: 0.93

CONS_SCORE: -199.8218

DSS_SCORE: 0.6192

HELIX: 0.0236

FCONS_SCORE: -892.8208

RIG_SCORE: 0.6396

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A170E	DO228985	LICA	ICGC	AESTT	DEG_SPOP_SBC_1	0.1111
p.T181K	DO229038	LICA	ICGC	AESTT	DEG_SPOP_SBC_1	0.7306
p.P190S	DO220891	MELA	ICGC	AESTT	DEG_SPOP_SBC_1	0.1111
p.P187S	DO222635	MELA	ICGC	AESTT	DEG_SPOP_SBC_1	0.1944
p.T182A	SIDM00221	Melanoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.7139
p.P186L	SIDM00670	Pancreatic Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.2222
p.P186L	SIDM00309	Mesothelioma	GDSC	AESTT	DEG_SPOP_SBC_1	0.2222
p.P186L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.2222
p.S180A	SIDM00154	Mesothelioma	GDSC	AESTT	DEG_SPOP_SBC_1	0.7588
p.S180A	ACH-002130	Lung Cancer	CCLE	AESTT	DEG_SPOP_SBC_1	0.7588
p.S180A	H2795	pleura	COSMIC	AESTT	DEG_SPOP_SBC_1	0.7588
p.K170Q	HCC2998	large_intestine	COSMIC	AESTT	DEG_SPOP_SBC_1	0.1111
p.R175C	LOXIMVI	skin	COSMIC	AESTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14594	Neurocan core protein	DEG_SPOP_SBC_1	854:858	AESTT	SPOP	0.7876	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6335:6339	AESTT	SPOP	0.5654	More...
Q99504	Eyes absent homolog 3	DEG_SPOP_SBC_1	227:231	AESTT	SPOP	0.9997	More...
Q99698	Lysosomal-trafficking regulator	DEG_SPOP_SBC_1	1487:1491	AESTT	SPOP	0.7185	More...
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_SPOP_SBC_1	178:182	AESTT	SPOP	0.9262	More...
Q9C093	Sperm flagellar protein 2	DEG_SPOP_SBC_1	548:552	AESTT	SPOP	0.8268	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4852:4856	AESTT	SPOP	0.6629	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons