DegronMD - Q99504(EYA3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S86T	TCGA-14-1451	GBM	TCGA	DYTSQMYSAKP	CBL_PTK	66:76	Mutation rewiring degron network	0.0556
p.M71I	TCGA-85-8276	LUSC	TCGA	DYTSQMYSAKP	CBL_PTK	66:76	Mutation altering degron motif	0.6507
p.S239L	TCGA-AX-A2HC	UCEC	TCGA	AESTT	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.1111
p.T220A	TCGA-B5-A3FA	UCEC	TCGA	AESTT	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.1389
p.S86L	TCGA-CK-4951	COAD	TCGA	DYTSQMYSAKP	CBL_PTK	66:76	Mutation rewiring degron network	0.0556
p.S138Y	TCGA-DA-A1HV	SKCM	TCGA	LIQTPSPS	DEG_SCF_FBW7_1	133:140	Mutation altering degron motif	0.712
p.T68A	TCGA-E6-A1LX	UCEC	TCGA	DYTSQMYSAKP	CBL_PTK	66:76	Mutation altering degron motif	0.6028
p.T136N	TCGA-QK-A6II	HNSC	TCGA	LIQTPSPS	DEG_SCF_FBW7_1	133:140	Mutation altering degron motif	0.7055
p.N65S	TCGA-V1-A9OT	PRAD	TCGA	DYTSQMYSAKP	CBL_PTK	66:76	Mutation rewiring degron network	0.3056
p.R62H	TCGA-VQ-A91D	STAD	TCGA	DYTSQMYSAKP	CBL_PTK	66:76	Mutation rewiring degron network	0.2222
p.M127I	TCGA-ZF-A9RC	BLCA	TCGA	LIQTPSPS	DEG_SCF_FBW7_1	133:140	Mutation rewiring degron network	0.1667
p.Q50E	DO48390	BLCA	ICGC	PETSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1111
p.D143Y	DO51926	BLCA	ICGC	LIQTPSPS	DEG_SCF_FBW7_1	133:140	Mutation rewiring degron network	0.25
p.D223H	DO219049	BLCA	ICGC	AESTT	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.2222
p.M74I	DO219068	BLCA	ICGC	DYTSQMYSAKP	CBL_PTK	66:76	Mutation altering degron motif	0.7618
p.L150V	DO2813	BRCA	ICGC	LIQTPSPS	DEG_SCF_FBW7_1	133:140	Mutation rewiring degron network	0.0556
p.T45P	DO6308	CESC	ICGC	PETSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.25
p.S33L	DO10582	COAD	ICGC	PETSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1944
p.L46P	DO9756	COAD	ICGC	PETSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.2222
p.L70V	DO222881	COCA	ICGC	DYTSQMYSAKP	CBL_PTK	66:76	Mutation altering degron motif	0.6765
p.Q57R	DO233179	GACA	ICGC	DYTSQMYSAKP	CBL_PTK	66:76	Mutation rewiring degron network	0.0833
p.S33T	DO13384	GBM	ICGC	PETSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1944
p.T83N	DO50006	HNSC	ICGC	DYTSQMYSAKP	CBL_PTK	66:76	Mutation rewiring degron network	0.1389
p.I149V	DO22321	LGG	ICGC	LIQTPSPS	DEG_SCF_FBW7_1	133:140	Mutation rewiring degron network	0.0833
p.P51L	DO231981	LICA	ICGC	PETSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.0833
p.Q224K	DO228952	LICA	ICGC	AESTT	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.25
p.Q40K	DO228952	LICA	ICGC	PETSS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.6944
p.Q40K	DO229041	LICA	ICGC	PETSS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.6944
p.T61K	DO228974	LICA	ICGC	DYTSQMYSAKP	CBL_PTK	66:76	Mutation rewiring degron network	0.1944
p.K232N	DO27176	LUSC	ICGC	AESTT	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.3056
p.S125F	DO222868	MELA	ICGC	LIQTPSPS	DEG_SCF_FBW7_1	133:140	Mutation rewiring degron network	0.1111
p.T59N	DO28093	OV	ICGC	DYTSQMYSAKP	CBL_PTK	66:76	Mutation rewiring degron network	0.1389
p.Q44H	DO32410	OV	ICGC	PETSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.2778
p.S85Y	DO37659	SKCM	ICGC	DYTSQMYSAKP	CBL_PTK	66:76	Mutation rewiring degron network	0.0833
p.P38S	DO50284	SKCM	ICGC	PETSS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.6752
p.P132S	DO47646	SKCM	ICGC	LIQTPSPS	DEG_SCF_FBW7_1	133:140	Mutation rewiring degron network	0.3056
p.G68C	DO47607	SKCM	ICGC	DYTSQMYSAKP	CBL_PTK	66:76	Mutation altering degron motif	0.76
p.K37T	ACH-000996	Endometrial/Uterine Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.3056
p.G39R	SN12C	kidney	COSMIC	PETSS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.7568
p.S236L	YKG-1	central nervous system	COSMIC	AESTT	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.1944
p.D142Y	HT-115	large intestine	COSMIC	LIQTPSPS	DEG_SCF_FBW7_1	133:140	Mutation rewiring degron network	0.2778

Kaplan plot for EYA3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EYA3

UniProt ID: Q99504

Entrez ID: 2140

Protein name: Eyes absent homolog 3 (EC 3.1.3.48)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EYA3 in