DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DYTSQMYSAKP
Uniprot ID:
Q99504
Source protein:
Eyes absent homolog 3
Source gene:
EYA3
Class:
CBL_PTK
Location:
66:76
E3 ligase:
CBL
DEGRON score:
0.9254
ASA_SCORE:
76.3273
COIL:
0.8379
CONS_SCORE:
0.314
DSS_SCORE:
0.3169
HELIX:
0.1047
FCONS_SCORE:
0.9319
RIG_SCORE:
0.7479
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S86T
TCGA-14-1451
GBM
TCGA
DYTSQMYSAKP
CBL_PTK
0.0556
p.M71I
TCGA-85-8276
LUSC
TCGA
DYTSQMYSAKP
CBL_PTK
0.6507
p.S86L
TCGA-CK-4951
COAD
TCGA
DYTSQMYSAKP
CBL_PTK
0.0556
p.T68A
TCGA-E6-A1LX
UCEC
TCGA
DYTSQMYSAKP
CBL_PTK
0.6028
p.N65S
TCGA-V1-A9OT
PRAD
TCGA
DYTSQMYSAKP
CBL_PTK
0.3056
p.R62H
TCGA-VQ-A91D
STAD
TCGA
DYTSQMYSAKP
CBL_PTK
0.2222
p.M74I
DO219068
BLCA
ICGC
DYTSQMYSAKP
CBL_PTK
0.7618
p.L70V
DO222881
COCA
ICGC
DYTSQMYSAKP
CBL_PTK
0.6765
p.Q57R
DO233179
GACA
ICGC
DYTSQMYSAKP
CBL_PTK
0.0833
p.T83N
DO50006
HNSC
ICGC
DYTSQMYSAKP
CBL_PTK
0.1389
p.T61K
DO228974
LICA
ICGC
DYTSQMYSAKP
CBL_PTK
0.1944
p.T59N
DO28093
OV
ICGC
DYTSQMYSAKP
CBL_PTK
0.1389
p.S85Y
DO37659
SKCM
ICGC
DYTSQMYSAKP
CBL_PTK
0.0833
p.G68C
DO47607
SKCM
ICGC
DYTSQMYSAKP
CBL_PTK
0.76
Drug responses associated with EYA3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DYTSQMYSAKP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q99504
Eyes absent homolog 3
CBL_PTK
66:76
DYTSQMYSAKP
CBL
0.9254
More...