DegronMD

Uniprot ID: Q99504

Source protein: Eyes absent homolog 3

Source gene: EYA3

Class: DEG_SPOP_SBC_1

Location: 227:231

E3 ligase: SPOP

DEGRON score: 0.9997

ASA_SCORE: 67.48

COIL: 0.8218

CONS_SCORE: 0.3261

DSS_SCORE: 0.5024

HELIX: 0.1016

FCONS_SCORE: 1.0223

RIG_SCORE: 0.7164

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S239L	TCGA-AX-A2HC	UCEC	TCGA	AESTT	DEG_SPOP_SBC_1	0.1111
p.T220A	TCGA-B5-A3FA	UCEC	TCGA	AESTT	DEG_SPOP_SBC_1	0.1389
p.D223H	DO219049	BLCA	ICGC	AESTT	DEG_SPOP_SBC_1	0.2222
p.Q224K	DO228952	LICA	ICGC	AESTT	DEG_SPOP_SBC_1	0.25
p.K232N	DO27176	LUSC	ICGC	AESTT	DEG_SPOP_SBC_1	0.3056
p.S236L	YKG-1	central_nervous_system	COSMIC	AESTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14594	Neurocan core protein	DEG_SPOP_SBC_1	854:858	AESTT	SPOP	0.7876	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6335:6339	AESTT	SPOP	0.5654	More...
Q99504	Eyes absent homolog 3	DEG_SPOP_SBC_1	227:231	AESTT	SPOP	0.9997	More...
Q99698	Lysosomal-trafficking regulator	DEG_SPOP_SBC_1	1487:1491	AESTT	SPOP	0.7185	More...
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_SPOP_SBC_1	178:182	AESTT	SPOP	0.9262	More...
Q9C093	Sperm flagellar protein 2	DEG_SPOP_SBC_1	548:552	AESTT	SPOP	0.8268	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4852:4856	AESTT	SPOP	0.6629	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons