DegronMD - Q9C093(SPEF2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N1185S	TCGA-17-Z022	LUAD	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.2222
p.F1435L	TCGA-19-5956	GBM	TCGA	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.1667
p.F1435L	TCGA-D1-A17Q	UCEC	TCGA	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.1667
p.E1203K	TCGA-4Z-AA7M	BLCA	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.1667
p.L1193F	TCGA-77-8140	LUSC	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation altering degron motif	0.6981
p.R1452S	TCGA-85-8277	LUSC	TCGA	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.1667
p.P1445L	TCGA-85-A512	LUSC	TCGA	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation altering degron motif	0.6471
p.A548V	TCGA-A5-A0G2	UCEC	TCGA	AESTT	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.5825
p.A548V	DO41235	UCEC	ICGC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.5825
p.A548V	SIDM00683	Prostate Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.5825
p.A548V	ACH-000977	lymph node	CCLE	AESTT	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.5825
p.A548V	LNCaP-Clone-FGC	prostate	COSMIC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.5825
p.R1190Q	TCGA-AG-3892	READ	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation altering degron motif	0.7329
p.R1190Q	TCGA-AX-A0J0	UCEC	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation altering degron motif	0.7329
p.S557L	TCGA-AP-A1E0	UCEC	TCGA	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1944
p.S557L	DO43154	UCEC	ICGC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1944
p.S543Y	TCGA-AX-A1CE	UCEC	TCGA	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1944
p.S543Y	DO42280	UCEC	ICGC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1944
p.R1187I	TCGA-AZ-4315	COAD	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.2778
p.R1187I	TCGA-EI-6917	READ	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.2778
p.L1206P	TCGA-B0-4816	KIRC	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.0833
p.A559V	TCGA-B5-A11E	UCEC	TCGA	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1389
p.A559V	DO41644	UCEC	ICGC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1389
p.F1188C	TCGA-D1-A16X	UCEC	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.3056
p.P553H	TCGA-DU-6392	LGG	TCGA	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.P553H	DO22237	LGG	ICGC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.S543F	TCGA-EE-A3JD	SKCM	TCGA	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1944
p.S543F	DO50299	SKCM	ICGC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1944
p.S1431G	TCGA-ER-A19N	SKCM	TCGA	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.0556
p.N1201K	TCGA-F4-6856	COAD	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.2222
p.N1201K	SIDM01126	Small Cell Lung Carcinoma	GDSC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.2222
p.P553S	TCGA-FW-A3TV	SKCM	TCGA	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.P553S	DO38159	SKCM	ICGC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.R1207G	TCGA-HD-7831	HNSC	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.0556
p.P545L	TCGA-KQ-A41S	BLCA	TCGA	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.25
p.P545L	DO223593	BLCA	ICGC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.25
p.R1452H	TCGA-LA-A7SW	LUSC	TCGA	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.1667
p.R538S	TCGA-S9-A6U6	LGG	TCGA	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0556
p.R538S	DO50190	LGG	ICGC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0556
p.P1448L	TCGA-Z2-A8RT	SKCM	TCGA	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.2778
p.E1198K	DO218976	BLCA	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.3056
p.I1186T	DO225386	BRCA	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation substituting flanking lysine	0.3611
p.N1180S	DO229355	BTCA	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.0833
p.N1196K	DO9114	COAD	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation altering degron motif	0.6918
p.R1182I	DO8842	COAD	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.1389
p.R1182I	DO36881	READ	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.1389
p.R1447H	DO227987	COCA	ICGC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.3056
p.R1447H	DO52024	LUSC	ICGC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.3056
p.R547Q	DO222762	COCA	ICGC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.I1436M	DO50399	ESAD	ICGC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.1944
p.G1434D	DO233652	GACA	ICGC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.1389
p.P1204T	DO51163	GBM	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.1389
p.R1202G	DO14272	HNSC	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.1944
p.L1201P	DO17075	KIRC	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.2222
p.R538M	DO228974	LICA	ICGC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0556
p.V1189F	DO229029	LICA	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation altering degron motif	0.7068
p.R1185Q	DO229050	LICA	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.2222
p.R1185Q	DO36394	READ	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.2222
p.R1185Q	DO41133	UCEC	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.2222
p.D1456V	DO231018	LUSC	ICGC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.0556
p.R547L	DO231165	LUSC	ICGC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.L1188F	DO26834	LUSC	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.3056
p.R1447S	DO26719	LUSC	ICGC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.3056
p.P1440L	DO45425	LUSC	ICGC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.3056
p.P1204L	DO220911	MELA	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.1389
p.N1433I	DO220913	MELA	ICGC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.1111
p.N1433I	ACH-000659	Lung Cancer	CCLE	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.1111
p.N1433I	ACH-001386	Lung Cancer	CCLE	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.1111
p.P1443L	DO222708	MELA	ICGC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation altering degron motif	0.7582
p.P1443L	DO51301	SKCM	ICGC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation altering degron motif	0.7582
p.L1201F	DO222721	MELA	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.2222
p.I1446M	DO232224	PBCA	ICGC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation altering degron motif	0.7618
p.E1454K	DO219482	SKCM	ICGC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.1111
p.K1453N	DO41999	UCEC	ICGC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.1389
p.F1183C	DO41799	UCEC	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.1667
p.A540V	SIDM01265	Plasma Cell Myeloma	GDSC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1111
p.A540V	SIDM01126	Small Cell Lung Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1111
p.A540V	SIDM00849	Kidney Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1111
p.A540V	SIDM00309	Mesothelioma	GDSC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1111
p.A540V	SIDM00032	Bladder Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1111
p.A540V	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1111
p.A540V	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1111
p.A540V	SIDM01752	Pancreatic Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1111
p.N1185K	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.2222
p.N1185K	NCI-H2172	lung	COSMIC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.2222
p.K1442N	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation altering degron motif	0.5806
p.K1442N	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation altering degron motif	0.5806
p.P545S	SIDM00627	Cervical Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.25
p.P545S	SIDM00789	Colorectal Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.25
p.P545S	SIDM00761	Small Cell Lung Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.25
p.P545S	SIDM00181	Bladder Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.25
p.P545S	SIDM01646	Non-Cancerous	GDSC	AESTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.25
p.D1197G	SIDM00086	Kidney Carcinoma	GDSC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation altering degron motif	0.6087
p.D1197G	RXF393	kidney	COSMIC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation altering degron motif	0.6087
p.P1181S	SIDM00006	Other Solid Cancers	GDSC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.1111
p.P1181S	MCC26	skin	COSMIC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.1111
p.D1434Y	SIDM00118	Colorectal Carcinoma	GDSC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.1389
p.D1434Y	HCC2998	large intestine	COSMIC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.1389
p.P1443S	ACH-000012	Lung Cancer	CCLE	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation altering degron motif	0.6752
p.P1443S	ACH-000029	Lung Cancer	CCLE	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation altering degron motif	0.6752
p.K1437N	ACH-000271	Lymphoma	CCLE	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.2222
p.K1437N	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	IKVFPD	LIG_APCC_ABBA_1	1441:1446	Mutation rewiring degron network	0.2222
p.N1180K	ACH-000924	Lung Cancer	CCLE	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.0833
p.N1180K	NCI-H2172	lung	COSMIC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.0833
p.L1205V	ACH-001099	Rhabdoid	CCLE	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.1111
p.D1192G	ACH-002195	Kidney Cancer	CCLE	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation altering degron motif	0.7198
p.D1192G	RXF393	kidney	COSMIC	TRIPLVQLD	DEG_APCC_DBOX_1	1189:1197	Mutation altering degron motif	0.7198

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPEF2

UniProt ID: Q9C093

Entrez ID: 79925

Protein name: Sperm flagellar protein 2 (Protein KPL2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPEF2 in