DegronMD

Uniprot ID: Q9C093

Source protein: Sperm flagellar protein 2

Source gene: SPEF2

Class: DEG_APCC_DBOX_1

Location: 1189:1197

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7613

ASA_SCORE: 60.3333

COIL: 0.636

CONS_SCORE: 0.4894

DSS_SCORE: 0.3418

HELIX: 0.0684

FCONS_SCORE: 1.2291

RIG_SCORE: 0.837

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1185S	TCGA-17-Z022	LUAD	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	0.2222
p.E1203K	TCGA-4Z-AA7M	BLCA	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	0.1667
p.L1193F	TCGA-77-8140	LUSC	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	0.6981
p.R1190Q	TCGA-AG-3892	READ	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	0.7329
p.R1190Q	TCGA-AX-A0J0	UCEC	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	0.7329
p.R1187I	TCGA-AZ-4315	COAD	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	0.2778
p.R1187I	TCGA-EI-6917	READ	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	0.2778
p.L1206P	TCGA-B0-4816	KIRC	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	0.0833
p.F1188C	TCGA-D1-A16X	UCEC	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	0.3056
p.N1201K	TCGA-F4-6856	COAD	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	0.2222
p.N1201K	SIDM01126	Small Cell Lung Carcinoma	GDSC	TRIPLVQLD	DEG_APCC_DBOX_1	0.2222
p.R1207G	TCGA-HD-7831	HNSC	TCGA	TRIPLVQLD	DEG_APCC_DBOX_1	0.0556
p.E1198K	DO218976	BLCA	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.3056
p.I1186T	DO225386	BRCA	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.3611
p.N1180S	DO229355	BTCA	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.0833
p.N1196K	DO9114	COAD	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.6918
p.R1182I	DO8842	COAD	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.1389
p.R1182I	DO36881	READ	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.1389
p.P1204T	DO51163	GBM	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.1389
p.R1202G	DO14272	HNSC	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.1944
p.L1201P	DO17075	KIRC	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.2222
p.V1189F	DO229029	LICA	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.7068
p.R1185Q	DO229050	LICA	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.2222
p.R1185Q	DO36394	READ	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.2222
p.R1185Q	DO41133	UCEC	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.2222
p.L1188F	DO26834	LUSC	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.3056
p.P1204L	DO220911	MELA	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.1389
p.L1201F	DO222721	MELA	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.2222
p.F1183C	DO41799	UCEC	ICGC	TRIPLVQLD	DEG_APCC_DBOX_1	0.1667
p.N1185K	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	TRIPLVQLD	DEG_APCC_DBOX_1	0.2222
p.N1185K	NCI-H2172	lung	COSMIC	TRIPLVQLD	DEG_APCC_DBOX_1	0.2222
p.D1197G	SIDM00086	Kidney Carcinoma	GDSC	TRIPLVQLD	DEG_APCC_DBOX_1	0.6087
p.D1197G	RXF393	kidney	COSMIC	TRIPLVQLD	DEG_APCC_DBOX_1	0.6087
p.P1181S	SIDM00006	Other Solid Cancers	GDSC	TRIPLVQLD	DEG_APCC_DBOX_1	0.1111
p.P1181S	MCC26	skin	COSMIC	TRIPLVQLD	DEG_APCC_DBOX_1	0.1111
p.N1180K	ACH-000924	Lung Cancer	CCLE	TRIPLVQLD	DEG_APCC_DBOX_1	0.0833
p.N1180K	NCI-H2172	lung	COSMIC	TRIPLVQLD	DEG_APCC_DBOX_1	0.0833
p.L1205V	ACH-001099	Rhabdoid	CCLE	TRIPLVQLD	DEG_APCC_DBOX_1	0.1111
p.D1192G	ACH-002195	Kidney Cancer	CCLE	TRIPLVQLD	DEG_APCC_DBOX_1	0.7198
p.D1192G	RXF393	kidney	COSMIC	TRIPLVQLD	DEG_APCC_DBOX_1	0.7198

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRIPLVQLD

Degron related mutations and impact score

Drug responses associated with SPEF2 mutations

All proteins holding degron of TRIPLVQLD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C093	Sperm flagellar protein 2	DEG_APCC_DBOX_1	1189:1197	TRIPLVQLD	APC,CDC20,FZR1	0.7613	More...