DegronMD

Uniprot ID: Q9C093

Source protein: Sperm flagellar protein 2

Source gene: SPEF2

Class: DEG_SPOP_SBC_1

Location: 548:552

E3 ligase: SPOP

DEGRON score: 0.8268

ASA_SCORE: 88.9

COIL: 0.931

CONS_SCORE: 0.476

DSS_SCORE: 0.4898

HELIX: 0.0288

FCONS_SCORE: 0.8688

RIG_SCORE: 0.664

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A548V	TCGA-A5-A0G2	UCEC	TCGA	AESTT	DEG_SPOP_SBC_1	0.5825
p.A548V	DO41235	UCEC	ICGC	AESTT	DEG_SPOP_SBC_1	0.5825
p.A548V	SIDM00683	Prostate Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.5825
p.A548V	ACH-000977	lymph_node	CCLE	AESTT	DEG_SPOP_SBC_1	0.5825
p.A548V	LNCaP-Clone-FGC	prostate	COSMIC	AESTT	DEG_SPOP_SBC_1	0.5825
p.S557L	TCGA-AP-A1E0	UCEC	TCGA	AESTT	DEG_SPOP_SBC_1	0.1944
p.S557L	DO43154	UCEC	ICGC	AESTT	DEG_SPOP_SBC_1	0.1944
p.S543Y	TCGA-AX-A1CE	UCEC	TCGA	AESTT	DEG_SPOP_SBC_1	0.1944
p.S543Y	DO42280	UCEC	ICGC	AESTT	DEG_SPOP_SBC_1	0.1944
p.A559V	TCGA-B5-A11E	UCEC	TCGA	AESTT	DEG_SPOP_SBC_1	0.1389
p.A559V	DO41644	UCEC	ICGC	AESTT	DEG_SPOP_SBC_1	0.1389
p.P553H	TCGA-DU-6392	LGG	TCGA	AESTT	DEG_SPOP_SBC_1	0.3056
p.P553H	DO22237	LGG	ICGC	AESTT	DEG_SPOP_SBC_1	0.3056
p.S543F	TCGA-EE-A3JD	SKCM	TCGA	AESTT	DEG_SPOP_SBC_1	0.1944
p.S543F	DO50299	SKCM	ICGC	AESTT	DEG_SPOP_SBC_1	0.1944
p.P553S	TCGA-FW-A3TV	SKCM	TCGA	AESTT	DEG_SPOP_SBC_1	0.3056
p.P553S	DO38159	SKCM	ICGC	AESTT	DEG_SPOP_SBC_1	0.3056
p.P545L	TCGA-KQ-A41S	BLCA	TCGA	AESTT	DEG_SPOP_SBC_1	0.25
p.P545L	DO223593	BLCA	ICGC	AESTT	DEG_SPOP_SBC_1	0.25
p.R538S	TCGA-S9-A6U6	LGG	TCGA	AESTT	DEG_SPOP_SBC_1	0.0556
p.R538S	DO50190	LGG	ICGC	AESTT	DEG_SPOP_SBC_1	0.0556
p.R547Q	DO222762	COCA	ICGC	AESTT	DEG_SPOP_SBC_1	0.3056
p.R538M	DO228974	LICA	ICGC	AESTT	DEG_SPOP_SBC_1	0.0556
p.R547L	DO231165	LUSC	ICGC	AESTT	DEG_SPOP_SBC_1	0.3056
p.A540V	SIDM01265	Plasma Cell Myeloma	GDSC	AESTT	DEG_SPOP_SBC_1	0.1111
p.A540V	SIDM01126	Small Cell Lung Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.1111
p.A540V	SIDM00849	Kidney Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.1111
p.A540V	SIDM00309	Mesothelioma	GDSC	AESTT	DEG_SPOP_SBC_1	0.1111
p.A540V	SIDM00032	Bladder Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.1111
p.A540V	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.1111
p.A540V	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.1111
p.A540V	SIDM01752	Pancreatic Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.1111
p.P545S	SIDM00627	Cervical Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.25
p.P545S	SIDM00789	Colorectal Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.25
p.P545S	SIDM00761	Small Cell Lung Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.25
p.P545S	SIDM00181	Bladder Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	0.25
p.P545S	SIDM01646	Non-Cancerous	GDSC	AESTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14594	Neurocan core protein	DEG_SPOP_SBC_1	854:858	AESTT	SPOP	0.7876	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6335:6339	AESTT	SPOP	0.5654	More...
Q99504	Eyes absent homolog 3	DEG_SPOP_SBC_1	227:231	AESTT	SPOP	0.9997	More...
Q99698	Lysosomal-trafficking regulator	DEG_SPOP_SBC_1	1487:1491	AESTT	SPOP	0.7185	More...
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_SPOP_SBC_1	178:182	AESTT	SPOP	0.9262	More...
Q9C093	Sperm flagellar protein 2	DEG_SPOP_SBC_1	548:552	AESTT	SPOP	0.8268	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4852:4856	AESTT	SPOP	0.6629	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AESTT

Degron related mutations and impact score

Drug responses associated with SPEF2 mutations

All proteins holding degron of AESTT