DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SPOP_SBC_1

Location: 4852:4856

E3 ligase: SPOP

DEGRON score: 0.6629

ASA_SCORE: 85.96

COIL: 0.6922

CONS_SCORE: 0

DSS_SCORE: 0.4541

HELIX: 0.0294

FCONS_SCORE: 0

RIG_SCORE: 0.7761

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F4853L	TCGA-LN-A9FP	ESCA	TCGA	AESTT	DEG_SPOP_SBC_1	0.6981
p.G4862S	DO218900	SKCA	ICGC	AESTT	DEG_SPOP_SBC_1	0.1667
p.G4862S	ACH-000796	Ovarian Cancer	CCLE	AESTT	DEG_SPOP_SBC_1	0.1667
p.E4853D	ACH-000773	Lymphoma	CCLE	AESTT	DEG_SPOP_SBC_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14594	Neurocan core protein	DEG_SPOP_SBC_1	854:858	AESTT	SPOP	0.7876	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6335:6339	AESTT	SPOP	0.5654	More...
Q99504	Eyes absent homolog 3	DEG_SPOP_SBC_1	227:231	AESTT	SPOP	0.9997	More...
Q99698	Lysosomal-trafficking regulator	DEG_SPOP_SBC_1	1487:1491	AESTT	SPOP	0.7185	More...
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_SPOP_SBC_1	178:182	AESTT	SPOP	0.9262	More...
Q9C093	Sperm flagellar protein 2	DEG_SPOP_SBC_1	548:552	AESTT	SPOP	0.8268	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4852:4856	AESTT	SPOP	0.6629	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons