DegronMD - Q99698(LYST)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K1498N	TCGA-AX-A2HC	UCEC	TCGA	AESTT	DEG_SPOP_SBC_1	1487:1491	Mutation substituting flanking lysine	0.25
p.K1498N	TCGA-B5-A1MR	UCEC	TCGA	AESTT	DEG_SPOP_SBC_1	1487:1491	Mutation substituting flanking lysine	0.25
p.K1498N	DO7801	COAD	ICGC	AESTT	DEG_SPOP_SBC_1	1487:1491	Mutation substituting flanking lysine	0.25
p.K1498N	DO41758	UCEC	ICGC	AESTT	DEG_SPOP_SBC_1	1487:1491	Mutation substituting flanking lysine	0.25
p.K1498N	DO41572	UCEC	ICGC	AESTT	DEG_SPOP_SBC_1	1487:1491	Mutation substituting flanking lysine	0.25
p.K1498M	TCGA-EM-A3SY	THCA	TCGA	AESTT	DEG_SPOP_SBC_1	1487:1491	Mutation substituting flanking lysine	0.25
p.K1498M	DO48063	THCA	ICGC	AESTT	DEG_SPOP_SBC_1	1487:1491	Mutation substituting flanking lysine	0.25
p.R1500I	DO7801	COAD	ICGC	AESTT	DEG_SPOP_SBC_1	1487:1491	Mutation rewiring degron network	0.0833
p.H1485N	DO228976	LICA	ICGC	AESTT	DEG_SPOP_SBC_1	1487:1491	Mutation rewiring degron network	0.2778
p.H1485N	DO220883	MELA	ICGC	AESTT	DEG_SPOP_SBC_1	1487:1491	Mutation rewiring degron network	0.2778
p.A1487D	DO229028	LICA	ICGC	AESTT	DEG_SPOP_SBC_1	1487:1491	Mutation altering degron motif	0.7793
p.E1486D	DO232761	PBCA	ICGC	AESTT	DEG_SPOP_SBC_1	1487:1491	Mutation rewiring degron network	0.3056
p.V1481A	SIDM00217	Colorectal Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	1487:1491	Mutation rewiring degron network	0.1667
p.V1481A	ACH-000999	Colon/Colorectal Cancer	CCLE	AESTT	DEG_SPOP_SBC_1	1487:1491	Mutation rewiring degron network	0.1667
p.V1481A	SNU-1040	large intestine	COSMIC	AESTT	DEG_SPOP_SBC_1	1487:1491	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons