DegronMD

Uniprot ID: Q9C093

Source protein: Sperm flagellar protein 2

Source gene: SPEF2

Class: LIG_APCC_ABBA_1

Location: 1441:1446

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7282

ASA_SCORE: 68.1333

COIL: 0.4085

CONS_SCORE: 0.4555

DSS_SCORE: 0.5167

HELIX: 0.0032

FCONS_SCORE: 0.8758

RIG_SCORE: 0.7196

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1435L	TCGA-19-5956	GBM	TCGA	IKVFPD	LIG_APCC_ABBA_1	0.1667
p.F1435L	TCGA-D1-A17Q	UCEC	TCGA	IKVFPD	LIG_APCC_ABBA_1	0.1667
p.R1452S	TCGA-85-8277	LUSC	TCGA	IKVFPD	LIG_APCC_ABBA_1	0.1667
p.P1445L	TCGA-85-A512	LUSC	TCGA	IKVFPD	LIG_APCC_ABBA_1	0.6471
p.S1431G	TCGA-ER-A19N	SKCM	TCGA	IKVFPD	LIG_APCC_ABBA_1	0.0556
p.R1452H	TCGA-LA-A7SW	LUSC	TCGA	IKVFPD	LIG_APCC_ABBA_1	0.1667
p.P1448L	TCGA-Z2-A8RT	SKCM	TCGA	IKVFPD	LIG_APCC_ABBA_1	0.2778
p.R1447H	DO227987	COCA	ICGC	IKVFPD	LIG_APCC_ABBA_1	0.3056
p.R1447H	DO52024	LUSC	ICGC	IKVFPD	LIG_APCC_ABBA_1	0.3056
p.I1436M	DO50399	ESAD	ICGC	IKVFPD	LIG_APCC_ABBA_1	0.1944
p.G1434D	DO233652	GACA	ICGC	IKVFPD	LIG_APCC_ABBA_1	0.1389
p.D1456V	DO231018	LUSC	ICGC	IKVFPD	LIG_APCC_ABBA_1	0.0556
p.R1447S	DO26719	LUSC	ICGC	IKVFPD	LIG_APCC_ABBA_1	0.3056
p.P1440L	DO45425	LUSC	ICGC	IKVFPD	LIG_APCC_ABBA_1	0.3056
p.N1433I	DO220913	MELA	ICGC	IKVFPD	LIG_APCC_ABBA_1	0.1111
p.N1433I	ACH-000659	Lung Cancer	CCLE	IKVFPD	LIG_APCC_ABBA_1	0.1111
p.N1433I	ACH-001386	Lung Cancer	CCLE	IKVFPD	LIG_APCC_ABBA_1	0.1111
p.P1443L	DO222708	MELA	ICGC	IKVFPD	LIG_APCC_ABBA_1	0.7582
p.P1443L	DO51301	SKCM	ICGC	IKVFPD	LIG_APCC_ABBA_1	0.7582
p.I1446M	DO232224	PBCA	ICGC	IKVFPD	LIG_APCC_ABBA_1	0.7618
p.E1454K	DO219482	SKCM	ICGC	IKVFPD	LIG_APCC_ABBA_1	0.1111
p.K1453N	DO41999	UCEC	ICGC	IKVFPD	LIG_APCC_ABBA_1	0.1389
p.K1442N	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	IKVFPD	LIG_APCC_ABBA_1	0.5806
p.K1442N	SU-DHL-10	haematopoietic_and_lymphoid_tissue	COSMIC	IKVFPD	LIG_APCC_ABBA_1	0.5806
p.D1434Y	SIDM00118	Colorectal Carcinoma	GDSC	IKVFPD	LIG_APCC_ABBA_1	0.1389
p.D1434Y	HCC2998	large_intestine	COSMIC	IKVFPD	LIG_APCC_ABBA_1	0.1389
p.P1443S	ACH-000012	Lung Cancer	CCLE	IKVFPD	LIG_APCC_ABBA_1	0.6752
p.P1443S	ACH-000029	Lung Cancer	CCLE	IKVFPD	LIG_APCC_ABBA_1	0.6752
p.K1437N	ACH-000271	Lymphoma	CCLE	IKVFPD	LIG_APCC_ABBA_1	0.2222
p.K1437N	SU-DHL-10	haematopoietic_and_lymphoid_tissue	COSMIC	IKVFPD	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IKVFPD

Degron related mutations and impact score

Drug responses associated with SPEF2 mutations

All proteins holding degron of IKVFPD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C093	Sperm flagellar protein 2	LIG_APCC_ABBA_1	1441:1446	IKVFPD	APC,CDC20,FZR1	0.7282	More...