DegronMD

Uniprot ID: Q99504

Source protein: Eyes absent homolog 3

Source gene: EYA3

Class: DEG_SCF_FBW7_1

Location: 133:140

E3 ligase: FBXW7

DEGRON score: 0.9774

ASA_SCORE: 56.8125

COIL: 0.8224

CONS_SCORE: 0.3005

DSS_SCORE: 0.5758

HELIX: 0.0825

FCONS_SCORE: 1.0391

RIG_SCORE: 0.6441

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S138Y	TCGA-DA-A1HV	SKCM	TCGA	LIQTPSPS	DEG_SCF_FBW7_1	0.712
p.T136N	TCGA-QK-A6II	HNSC	TCGA	LIQTPSPS	DEG_SCF_FBW7_1	0.7055
p.M127I	TCGA-ZF-A9RC	BLCA	TCGA	LIQTPSPS	DEG_SCF_FBW7_1	0.1667
p.D143Y	DO51926	BLCA	ICGC	LIQTPSPS	DEG_SCF_FBW7_1	0.25
p.L150V	DO2813	BRCA	ICGC	LIQTPSPS	DEG_SCF_FBW7_1	0.0556
p.I149V	DO22321	LGG	ICGC	LIQTPSPS	DEG_SCF_FBW7_1	0.0833
p.S125F	DO222868	MELA	ICGC	LIQTPSPS	DEG_SCF_FBW7_1	0.1111
p.P132S	DO47646	SKCM	ICGC	LIQTPSPS	DEG_SCF_FBW7_1	0.3056
p.D142Y	HT-115	large_intestine	COSMIC	LIQTPSPS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99504	Eyes absent homolog 3	DEG_SCF_FBW7_1	133:140	LIQTPSPS	FBXW7	0.9774	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons