DegronMD

Uniprot ID: Q9P2R6

Source protein: Arginine-glutamic acid dipeptide repeats protein

Source gene: RERE

Class: DEG_SCF_FBW7_1

Location: 761:767

E3 ligase: FBXW7

DEGRON score: 0.7558

ASA_SCORE: 88.3286

COIL: 0.9764

CONS_SCORE: 0.4466

DSS_SCORE: 0.8509

HELIX: 0.0083

FCONS_SCORE: 1.0206

RIG_SCORE: 0.4929

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A770V	TCGA-CN-5369	HNSC	TCGA	LPTPGPT	DEG_SCF_FBW7_1	0.25
p.A770V	DO16069	HNSC	ICGC	LPTPGPT	DEG_SCF_FBW7_1	0.25
p.G757E	TCGA-GN-A4U3	SKCM	TCGA	LPTPGPT	DEG_SCF_FBW7_1	0.2222
p.G757E	DO219484	SKCM	ICGC	LPTPGPT	DEG_SCF_FBW7_1	0.2222
p.P766L	TCGA-IB-AAUU	PAAD	TCGA	LPTPGPT	DEG_SCF_FBW7_1	0.6471
p.P766L	DO51712	PAAD	ICGC	LPTPGPT	DEG_SCF_FBW7_1	0.6471
p.A772T	DO229253	THCA	ICGC	LPTPGPT	DEG_SCF_FBW7_1	0.1944
p.P774S	ACH-000894	Lung Cancer	CCLE	LPTPGPT	DEG_SCF_FBW7_1	0.1389
p.G757A	ACH-001795	Liposarcoma	CCLE	LPTPGPT	DEG_SCF_FBW7_1	0.2222
p.R763Q	NCI-H1155	lung	COSMIC	LPTPGPT	DEG_SCF_FBW7_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2R6	Arginine-glutamic acid dipeptide repeats protein	DEG_SCF_FBW7_1	761:767	LPTPGPT	FBXW7	0.7558	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons