DegronMD

Uniprot ID: Q9P2R6

Source protein: Arginine-glutamic acid dipeptide repeats protein

Source gene: RERE

Class: DEG_SPOP_SBC_1

Location: 616:620

E3 ligase: SPOP

DEGRON score: 0.997

ASA_SCORE: 82.14

COIL: 0.8614

CONS_SCORE: 0.4328

DSS_SCORE: 0.6901

HELIX: 0.1296

FCONS_SCORE: 1.046

RIG_SCORE: 0.5268

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S609T	TCGA-12-0829	GBM	TCGA	AASTS	DEG_SPOP_SBC_1	0.5833
p.S609T	DO11166	GBM	ICGC	AASTS	DEG_SPOP_SBC_1	0.5833
p.A616T	TCGA-AM-5821	COAD	TCGA	AASTS	DEG_SPOP_SBC_1	0.7139
p.A616T	DO8240	COAD	ICGC	AASTS	DEG_SPOP_SBC_1	0.7139
p.S609G	TCGA-D1-A167	UCEC	TCGA	AASTS	DEG_SPOP_SBC_1	0.5833
p.S609G	DO40978	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	0.5833
p.S621G	TCGA-HE-A5NI	KIRP	TCGA	AASTS	DEG_SPOP_SBC_1	0.75
p.S621G	DO49767	KIRP	ICGC	AASTS	DEG_SPOP_SBC_1	0.75
p.R611W	DO230311	COCA	ICGC	AASTS	DEG_SPOP_SBC_1	0.1944
p.N622D	DO231934	LICA	ICGC	AASTS	DEG_SPOP_SBC_1	0.2778
p.T628K	DO229029	LICA	ICGC	AASTS	DEG_SPOP_SBC_1	0.1111
p.S615N	SIDM00447	B-Lymphoblastic Leukemia	GDSC	AASTS	DEG_SPOP_SBC_1	0.75
p.S615N	ACH-000960	Leukemia	CCLE	AASTS	DEG_SPOP_SBC_1	0.75
p.S615N	REH	haematopoietic_and_lymphoid_tissue	COSMIC	AASTS	DEG_SPOP_SBC_1	0.75
p.R607H	SIDM00618	Hepatocellular Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.0833
p.R607H	ACH-000620	Liver Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	0.0833
p.R607H	JHH-1	liver	COSMIC	AASTS	DEG_SPOP_SBC_1	0.0833
p.G610C	ACH-000385	Kidney Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	0.1667
p.E626V	HCC1569	breast	COSMIC	AASTS	DEG_SPOP_SBC_1	0.1667
p.R625L	CHP-212	autonomic_ganglia	COSMIC	AASTS	DEG_SPOP_SBC_1	0.3056
p.R630Q	LXF-289	lung	COSMIC	AASTS	DEG_SPOP_SBC_1	0.1667
p.R625Q	SU-DHL-5	haematopoietic_and_lymphoid_tissue	COSMIC	AASTS	DEG_SPOP_SBC_1	0.3056
p.R618C	HCT-116	large_intestine	COSMIC	AASTS	DEG_SPOP_SBC_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15391	Transcription factor YY2	DEG_SPOP_SBC_1	127:131	AASTS	SPOP	0.8632	More...
O15504	Nucleoporin NUP42	DEG_SPOP_SBC_1	274:278	AASTS	SPOP	0.5936	More...
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	122:126	AASTS	SPOP	0.9939	More...
O75113	NEDD4-binding protein 1	DEG_SPOP_SBC_1	804:808	AASTS	SPOP	0.9913	More...
O95259	Potassium voltage-gated channel subfamily H member 1	DEG_SPOP_SBC_1	802:806	AASTS	SPOP	0.8742	More...
O95721	Synaptosomal-associated protein 29	DEG_SPOP_SBC_1	57:61	AASTS	SPOP	0.8495	More...
P11473	Vitamin D3 receptor	DEG_SPOP_SBC_1	5:9	AASTS	SPOP	0.7318	More...
P18827	Syndecan-1	DEG_SPOP_SBC_1	87:91	AASTS	SPOP	0.9596	More...
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	21:25	AASTS	SPOP	0.9238	More...
Q13049	E3 ubiquitin-protein ligase TRIM32	DEG_SPOP_SBC_1	315:319	AASTS	SPOP	0.925	More...
Q14669	E3 ubiquitin-protein ligase TRIP12	DEG_SPOP_SBC_1	199:203	AASTS	SPOP	0.9879	More...
Q2KHT3	Protein CLEC16A	DEG_SPOP_SBC_1	450:454	AASTS	SPOP	0.6135	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	1155:1159	AASTS	SPOP	0.7759	More...
Q8IYG6	Leucine-rich repeat-containing protein 56	DEG_SPOP_SBC_1	363:367	AASTS	SPOP	0.8439	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2095:2099	AASTS	SPOP	0.5839	More...
Q9BWF3	RNA-binding protein 4	DEG_SPOP_SBC_1	298:302	AASTS	SPOP	0.9032	More...
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_SPOP_SBC_1	14:18	AASTS	SPOP	0.9981	More...
Q9P2R6	Arginine-glutamic acid dipeptide repeats protein	DEG_SPOP_SBC_1	616:620	AASTS	SPOP	0.997	More...
Q9UJX2	Cell division cycle protein 23 homolog	DEG_SPOP_SBC_1	2:6	AASTS	SPOP	0.5243	More...
O95081	Arf-GAP domain and FG repeat-containing protein 2	DEG_SPOP_SBC_1	189:193	AASTS	SPOP	0.9166	More...
Q8TC56	Golgi associated RAB2 interactor protein 3	DEG_SPOP_SBC_1	348:352	AASTS	SPOP	0.9521	More...
A6NL46	Putative UPF0607 protein ENSP00000332738	DEG_SPOP_SBC_1	108:112	AASTS	SPOP	0.9403	More...
A8MUA0	Putative UPF0607 protein ENSP00000381514	DEG_SPOP_SBC_1	109:113	AASTS	SPOP	0.7629	More...
A8MV72	Putative UPF0607 protein ENSP00000382826	DEG_SPOP_SBC_1	79:83	AASTS	SPOP	0.8388	More...
A8MX80	Putative UPF0607 protein ENSP00000383144	DEG_SPOP_SBC_1	109:113	AASTS	SPOP	0.6735	More...
Q5PR19	Putative UPF0607 protein LOC392364	DEG_SPOP_SBC_1	146:150	AASTS	SPOP	0.6539	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	414:418	AASTS	SPOP	0.97	More...
Q8N9G6	Putative UPF0607 protein FLJ37424	DEG_SPOP_SBC_1	109:113	AASTS	SPOP	0.878	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASTS

Degron related mutations and impact score

Drug responses associated with RERE mutations

All proteins holding degron of AASTS