DegronMD - Q71RG4(TMUB2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A157V	TCGA-BA-A6DJ	HNSC	TCGA	AGSSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.25
p.P250S	TCGA-BA-A6DJ	HNSC	TCGA	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation rewiring degron network	0.1667
p.P144H	TCGA-F4-6703	COAD	TCGA	AGSSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1667
p.V277A	TCGA-FI-A2D5	UCEC	TCGA	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation rewiring degron network	0.0833
p.S265C	TCGA-FP-8211	STAD	TCGA	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation altering degron motif	0.643
p.P148S	DO3146	BRCA	ICGC	AGSSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2778
p.R269Q	DO8264	COAD	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation rewiring degron network	0.3056
p.R269Q	DO10871	GBM	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation rewiring degron network	0.3056
p.R269Q	DO41020	UCEC	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation rewiring degron network	0.3056
p.R269Q	DO41235	UCEC	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation rewiring degron network	0.3056
p.M254V	DO233888	GACA	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation rewiring degron network	0.2778
p.M254V	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation rewiring degron network	0.2778
p.T145I	DO52034	HNSC	ICGC	AGSSS	DEG_SPOP_SBC_1	150:154	Mutation blocking ubiquitination signal	0.6389
p.V260L	DO228952	LICA	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation altering degron motif	0.6765
p.V156L	DO229032	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2778
p.V255L	DO50828	LICA	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation rewiring degron network	0.3056
p.P149L	DO222875	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.3056
p.S150N	DO46657	PAAD	ICGC	AGSSS	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7069
p.A278V	DO221547	PACA	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation rewiring degron network	0.0556
p.V257A	DO41331	UCEC	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation altering degron motif	0.6936
p.S164N	SIDM01004	Chronic Myelogenous Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	150:154	Mutation blocking phosphorylation signal	0.5
p.S164N	ACH-000983	Leukemia	CCLE	AGSSS	DEG_SPOP_SBC_1	150:154	Mutation blocking phosphorylation signal	0.5
p.S164N	KCL-22	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	150:154	Mutation blocking phosphorylation signal	0.5
p.A150T	SIDM00072	Non-Cancerous	GDSC	AGSSS	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7139
p.A150T	ACH-000206	Lymphoma	CCLE	AGSSS	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7139
p.M274V	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation rewiring degron network	0.1667
p.M274V	ACH-000918	Leukemia	CCLE	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation rewiring degron network	0.1667
p.M274V	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation rewiring degron network	0.1667
p.S144N	KCL-22	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1667
p.V260E	NCI-H660	prostate	COSMIC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	256:268	Mutation altering degron motif	0.7693
p.L162P	SNU-C5	large intestine	COSMIC	AGSSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMUB2

UniProt ID: Q71RG4

Entrez ID: 79089

Protein name: Transmembrane and ubiquitin-like domain-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMUB2 in