DegronMD

Uniprot ID: Q71RG4

Source protein: Transmembrane and ubiquitin-like domain-containing protein 2

Source gene: TMUB2

Class: DEG_ODPH_VHL_1

Location: 256:268

E3 ligase: VHL

DEGRON score: 0.9207

ASA_SCORE: 79.3154

COIL: 0.9248

CONS_SCORE: 0.3861

DSS_SCORE: 0.2966

HELIX: 0.0487

FCONS_SCORE: 0.6923

RIG_SCORE: 0.6715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P250S	TCGA-BA-A6DJ	HNSC	TCGA	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.1667
p.V277A	TCGA-FI-A2D5	UCEC	TCGA	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.0833
p.S265C	TCGA-FP-8211	STAD	TCGA	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.643
p.R269Q	DO8264	COAD	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.3056
p.R269Q	DO10871	GBM	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.3056
p.R269Q	DO41020	UCEC	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.3056
p.R269Q	DO41235	UCEC	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.3056
p.M254V	DO233888	GACA	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.2778
p.M254V	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.2778
p.V260L	DO228952	LICA	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.6765
p.V255L	DO50828	LICA	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.3056
p.A278V	DO221547	PACA	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.0556
p.V257A	DO41331	UCEC	ICGC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.6936
p.M274V	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.1667
p.M274V	ACH-000918	Leukemia	CCLE	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.1667
p.M274V	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.1667
p.V260E	NCI-H660	prostate	COSMIC	LAPSATEPPSLGV	DEG_ODPH_VHL_1	0.7693

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q71RG4	Transmembrane and ubiquitin-like domain-containing protein 2	DEG_ODPH_VHL_1	256:268	LAPSATEPPSLGV	VHL	0.9207	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons