DegronMD - O95071(UBR5)

FUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in matu... View more >>

GO - Biological processes (BP): cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; negative regulation of double-strand break repair [GO:2000780]; negative regulation of histone H2A K63-linked ubiquitination [GO:1901315]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive reg... View more >>

GO - Molecular function (MF): RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270]

GO - Cellular component (CC): cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R285C	DO48213	ESCA	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.8301
p.R290M	TCGA-NJ-A4YF	LUAD	TCGA	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.7521
p.R290M	DO218940	LUAD	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.7521
p.S1729C	DO590	BLCA	ICGC	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation blocking phosphorylation signal	0.75
p.R978Q	DO9002	COAD	ICGC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation altering degron motif	0.7329
p.S1728I	TCGA-49-AARQ	LUAD	TCGA	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation blocking phosphorylation signal	0.7222
p.R284C	TCGA-B5-A11E	UCEC	TCGA	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.719
p.R284C	DO41644	UCEC	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.719
p.S686Y	TCGA-A5-A0G1	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation altering degron motif	0.712
p.S982N	ACH-000037	Sarcoma	CCLE	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation altering degron motif	0.7069
p.M985L	DO51235	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation blocking phosphorylation signal	0.6944
p.M985T	DO38192	STAD	ICGC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation blocking phosphorylation signal	0.6944
p.A1732V	ACH-000999	Colon/Colorectal Cancer	CCLE	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation altering degron motif	0.6936
p.A1732V	SNU-1040	large intestine	COSMIC	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation altering degron motif	0.6936
p.N684D	ACH-000523	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation altering degron motif	0.6932
p.N684D	ACH-000733	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation altering degron motif	0.6932
p.N684D	NCI-H1838	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation altering degron motif	0.6932
p.P683S	TCGA-EE-A2GP	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation altering degron motif	0.6752
p.Y1740F	DO225276	BRCA	ICGC	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation blocking phosphorylation signal	0.6111
p.R971Q	DO45217	LIRI	ICGC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation blocking phosphorylation signal	0.5833

Showing 1 to 20 of 72 entries

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Kaplan plot for UBR5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBR5

UniProt ID: O95071

Entrez ID: 51366

Protein name: E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBR5 in