DegronMD - O95071(UBR5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S694I	TCGA-33-4566	LUSC	TCGA	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation rewiring degron network	0.1389
p.M991L	TCGA-3N-A9WD	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.0833
p.S1728I	TCGA-49-AARQ	LUAD	TCGA	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation blocking phosphorylation signal	0.7222
p.S686Y	TCGA-A5-A0G1	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation altering degron motif	0.712
p.V673A	TCGA-A5-A0G1	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation rewiring degron network	0.0556
p.R984Q	TCGA-AA-3984	COAD	TCGA	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.2778
p.R977W	TCGA-AP-A1DV	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.3056
p.R284C	TCGA-B5-A11E	UCEC	TCGA	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.719
p.R284C	DO41644	UCEC	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.719
p.P697L	TCGA-BG-A221	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation rewiring degron network	0.0556
p.R295Q	TCGA-BR-8680	STAD	TCGA	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.25
p.R295Q	DO47769	STAD	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.25
p.R295Q	SIDM00193	Colorectal Carcinoma	GDSC	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.25
p.R295Q	ACH-000991	Colon/Colorectal Cancer	CCLE	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.25
p.R295Q	SNU-81	large intestine	COSMIC	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.25
p.M991T	TCGA-CG-5721	STAD	TCGA	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.0833
p.L299V	TCGA-CQ-7064	HNSC	TCGA	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.1389
p.L299V	DO14162	HNSC	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.1389
p.P683S	TCGA-EE-A2GP	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation altering degron motif	0.6752
p.D274Y	TCGA-F5-6814	READ	TCGA	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.0556
p.D274Y	DO36556	READ	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.0556
p.S1735C	TCGA-G2-A3VY	BLCA	TCGA	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation rewiring degron network	0.3056
p.S276I	TCGA-IB-7651	PAAD	TCGA	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.1111
p.S276I	DO46657	PAAD	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.1111
p.R290M	TCGA-NJ-A4YF	LUAD	TCGA	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.7521
p.R290M	DO218940	LUAD	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.7521
p.D674G	TCGA-YF-AA3L	BLCA	TCGA	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation rewiring degron network	0.0833
p.S1729C	DO590	BLCA	ICGC	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation blocking phosphorylation signal	0.75
p.S989L	DO225209	BRCA	ICGC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.1389
p.Y1740F	DO225276	BRCA	ICGC	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation blocking phosphorylation signal	0.6111
p.T679N	DO224654	BRCA	ICGC	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation rewiring degron network	0.2222
p.R978Q	DO9002	COAD	ICGC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation altering degron motif	0.7329
p.R285C	DO48213	ESCA	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.8301
p.G969D	DO233738	GACA	ICGC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.0833
p.D692H	DO220587	KICH	ICGC	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation rewiring degron network	0.1944
p.S989P	DO22237	LGG	ICGC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.1389
p.A1721D	DO229019	LICA	ICGC	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation rewiring degron network	0.0833
p.A1724D	DO229028	LICA	ICGC	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation rewiring degron network	0.1667
p.T1723K	DO229031	LICA	ICGC	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation rewiring degron network	0.1389
p.A972D	DO229006	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.1667
p.R971Q	DO45217	LIRI	ICGC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation blocking phosphorylation signal	0.5833
p.S1722I	DO51189	LUAD	ICGC	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation rewiring degron network	0.1111
p.S688I	DO26790	LUSC	ICGC	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation rewiring degron network	0.3056
p.A1720S	DO27326	LUSC	ICGC	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation rewiring degron network	0.0556
p.A1720T	DO232070	ORCA	ICGC	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation rewiring degron network	0.0556
p.P677S	DO37422	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation rewiring degron network	0.1667
p.M985L	DO51235	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation blocking phosphorylation signal	0.6944
p.M985T	DO38192	STAD	ICGC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation blocking phosphorylation signal	0.6944
p.P691L	DO42384	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation rewiring degron network	0.2222
p.R971W	DO43186	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation blocking phosphorylation signal	0.5833
p.R988H	DO42608	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.1667
p.S680Y	DO42472	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation rewiring degron network	0.25
p.A693T	DO42665	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation rewiring degron network	0.1667
p.N690D	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation rewiring degron network	0.25
p.N690D	SIDM01679	Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation rewiring degron network	0.25
p.N690D	NCI-H1838	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation rewiring degron network	0.25
p.R989Q	SIDM00498	Colorectal Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.1389
p.R989Q	SNU-C5	large intestine	COSMIC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.1389
p.V968I	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.0556
p.V968I	NCI-H1437	lung	COSMIC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.0556
p.A1738V	SIDM00217	Colorectal Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation rewiring degron network	0.2222
p.A1738V	SNU-1040	large intestine	COSMIC	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation rewiring degron network	0.2222
p.S982N	ACH-000037	Sarcoma	CCLE	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation altering degron motif	0.7069
p.N684D	ACH-000523	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation altering degron motif	0.6932
p.N684D	ACH-000733	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation altering degron motif	0.6932
p.N684D	NCI-H1838	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation altering degron motif	0.6932
p.V673I	ACH-000941	Endometrial/Uterine Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	683:687	Mutation rewiring degron network	0.0556
p.R983Q	ACH-000970	Colon/Colorectal Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.3056
p.R983Q	SNU-C5	large intestine	COSMIC	AGSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.3056
p.A1738T	ACH-000998	Colon/Colorectal Cancer	CCLE	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation rewiring degron network	0.2222
p.A1732V	ACH-000999	Colon/Colorectal Cancer	CCLE	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation altering degron motif	0.6936
p.A1732V	SNU-1040	large intestine	COSMIC	APSST	DEG_SPOP_SBC_1	1730:1734	Mutation altering degron motif	0.6936

Kaplan plot for UBR5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBR5

UniProt ID: O95071

Entrez ID: 51366

Protein name: E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBR5 in