DegronMD

Uniprot ID: O95071

Source protein: E3 ubiquitin-protein ligase UBR5

Source gene: UBR5

Class: DEG_APCC_DBOX_1

Location: 284:292

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6408

ASA_SCORE: 80.5444

COIL: 0.7458

CONS_SCORE: 0.4025

DSS_SCORE: 0.0922

HELIX: 0.2166

FCONS_SCORE: 0.9449

RIG_SCORE: 0.7151

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R284C	TCGA-B5-A11E	UCEC	TCGA	RRSSLSRLG	DEG_APCC_DBOX_1	0.719
p.R284C	DO41644	UCEC	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	0.719
p.R295Q	TCGA-BR-8680	STAD	TCGA	RRSSLSRLG	DEG_APCC_DBOX_1	0.25
p.R295Q	DO47769	STAD	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	0.25
p.R295Q	SIDM00193	Colorectal Carcinoma	GDSC	RRSSLSRLG	DEG_APCC_DBOX_1	0.25
p.R295Q	ACH-000991	Colon/Colorectal Cancer	CCLE	RRSSLSRLG	DEG_APCC_DBOX_1	0.25
p.R295Q	SNU-81	large_intestine	COSMIC	RRSSLSRLG	DEG_APCC_DBOX_1	0.25
p.L299V	TCGA-CQ-7064	HNSC	TCGA	RRSSLSRLG	DEG_APCC_DBOX_1	0.1389
p.L299V	DO14162	HNSC	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	0.1389
p.D274Y	TCGA-F5-6814	READ	TCGA	RRSSLSRLG	DEG_APCC_DBOX_1	0.0556
p.D274Y	DO36556	READ	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	0.0556
p.S276I	TCGA-IB-7651	PAAD	TCGA	RRSSLSRLG	DEG_APCC_DBOX_1	0.1111
p.S276I	DO46657	PAAD	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	0.1111
p.R290M	TCGA-NJ-A4YF	LUAD	TCGA	RRSSLSRLG	DEG_APCC_DBOX_1	0.7521
p.R290M	DO218940	LUAD	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	0.7521
p.R285C	DO48213	ESCA	ICGC	RRSSLSRLG	DEG_APCC_DBOX_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95071	E3 ubiquitin-protein ligase UBR5	DEG_APCC_DBOX_1	284:292	RRSSLSRLG	APC,CDC20,FZR1	0.6408	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons