DegronMD - Q96QT4(TRPM7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P502S	TCGA-90-A4ED	LUSC	TCGA	PPGY	ITCH	502:505	Mutation altering degron motif	0.6752
p.P502S	DO45482	LUSC	ICGC	PPGY	ITCH	502:505	Mutation altering degron motif	0.6752
p.P502S	DO218906	SKCA	ICGC	PPGY	ITCH	502:505	Mutation altering degron motif	0.6752
p.T1830M	TCGA-A5-A0G2	UCEC	TCGA	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	1826:1833	Mutation altering degron motif	0.8534
p.T1830M	TCGA-VQ-A8PT	STAD	TCGA	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	1826:1833	Mutation altering degron motif	0.8534
p.Q498H	TCGA-A5-A0G2	UCEC	TCGA	PPGY	ITCH	502:505	Mutation rewiring degron network	0.2222
p.Q498H	DO41235	UCEC	ICGC	PPGY	ITCH	502:505	Mutation rewiring degron network	0.2222
p.V1558M	TCGA-AA-3861	COAD	TCGA	ERNNLMRLS	DEG_APCC_DBOX_1	1559:1567	Mutation rewiring degron network	0.3056
p.R1366Q	TCGA-AP-A1DV	UCEC	TCGA	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.7329
p.R1366Q	TCGA-EI-6917	READ	TCGA	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.7329
p.R1366Q	DO36881	READ	ICGC	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.7329
p.R1366Q	DO43186	UCEC	ICGC	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.7329
p.Q1367H	TCGA-B5-A11E	UCEC	TCGA	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.647
p.Q1367H	DO41644	UCEC	ICGC	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.647
p.P1357S	TCGA-BF-A5ER	SKCM	TCGA	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation rewiring degron network	0.1111
p.P1357S	TCGA-BF-A5ER	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.1944
p.P1357S	DO219454	SKCM	ICGC	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation rewiring degron network	0.1111
p.P1357S	DO219454	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.1944
p.K506N	TCGA-D1-A103	UCEC	TCGA	PPGY	ITCH	502:505	Mutation rewiring degron network	0.3056
p.K506N	DO42312	UCEC	ICGC	PPGY	ITCH	502:505	Mutation rewiring degron network	0.3056
p.R1340I	TCGA-E6-A1LX	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.1111
p.R1340I	DO41020	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.1111
p.D1839Y	TCGA-EE-A17Z	SKCM	TCGA	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	1826:1833	Mutation rewiring degron network	0.1667
p.P1837H	TCGA-EE-A181	SKCM	TCGA	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	1826:1833	Mutation rewiring degron network	0.2222
p.L501I	TCGA-EO-A22X	UCEC	TCGA	PPGY	ITCH	502:505	Mutation rewiring degron network	0.3056
p.L501I	DO43907	UCEC	ICGC	PPGY	ITCH	502:505	Mutation rewiring degron network	0.3056
p.Y1555C	TCGA-F7-A624	HNSC	TCGA	ERNNLMRLS	DEG_APCC_DBOX_1	1559:1567	Mutation rewiring degron network	0.2222
p.L509V	TCGA-HE-7130	KIRP	TCGA	PPGY	ITCH	502:505	Mutation rewiring degron network	0.2222
p.L509V	DO20776	KIRP	ICGC	PPGY	ITCH	502:505	Mutation rewiring degron network	0.2222
p.V1557M	DO9562	COAD	ICGC	ERNNLMRLS	DEG_APCC_DBOX_1	1559:1567	Mutation rewiring degron network	0.2778
p.E1373Q	DO222437	ESCA	ICGC	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.5633
p.D1831N	DO222744	ESCA	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	1826:1833	Mutation altering degron motif	0.6932
p.I507V	DO233142	GACA	ICGC	PPGY	ITCH	502:505	Mutation rewiring degron network	0.2778
p.D495H	DO233832	GACA	ICGC	PPGY	ITCH	502:505	Mutation rewiring degron network	0.1389
p.Y1554C	DO44440	HNSC	ICGC	ERNNLMRLS	DEG_APCC_DBOX_1	1559:1567	Mutation rewiring degron network	0.1944
p.Y1554C	DO230976	LUSC	ICGC	ERNNLMRLS	DEG_APCC_DBOX_1	1559:1567	Mutation rewiring degron network	0.1944
p.Y1554C	DO224626	LUSC	ICGC	ERNNLMRLS	DEG_APCC_DBOX_1	1559:1567	Mutation rewiring degron network	0.1944
p.Q498K	DO228948	LICA	ICGC	PPGY	ITCH	502:505	Mutation rewiring degron network	0.2222
p.Q498K	DO229034	LICA	ICGC	PPGY	ITCH	502:505	Mutation rewiring degron network	0.2222
p.P1840T	DO229019	LICA	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	1826:1833	Mutation rewiring degron network	0.1389
p.P1570Q	DO229019	LICA	ICGC	ERNNLMRLS	DEG_APCC_DBOX_1	1559:1567	Mutation rewiring degron network	0.25
p.Q1567K	DO229031	LICA	ICGC	ERNNLMRLS	DEG_APCC_DBOX_1	1559:1567	Mutation altering degron motif	0.6944
p.T1550K	DO229037	LICA	ICGC	ERNNLMRLS	DEG_APCC_DBOX_1	1559:1567	Mutation rewiring degron network	0.0833
p.P1836S	DO222546	MELA	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	1826:1833	Mutation rewiring degron network	0.25
p.P1836H	DO37444	SKCM	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	1826:1833	Mutation rewiring degron network	0.25
p.D1838Y	DO37921	SKCM	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	1826:1833	Mutation rewiring degron network	0.1944
p.T1829M	DO51776	STAD	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	1826:1833	Mutation altering degron motif	0.7423
p.T1829M	DO41235	UCEC	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	1826:1833	Mutation altering degron motif	0.7423
p.V515A	DO229213	THCA	ICGC	PPGY	ITCH	502:505	Mutation rewiring degron network	0.0556
p.P1362S	SIDM00197	Ewing's Sarcoma	GDSC	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation rewiring degron network	0.25
p.P1362S	SIDM00197	Ewing's Sarcoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.0556
p.P1362S	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation rewiring degron network	0.25
p.P1362S	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.0556
p.P1362S	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation rewiring degron network	0.25
p.P1362S	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.0556
p.Q498R	SIDM00516	Melanoma	GDSC	PPGY	ITCH	502:505	Mutation rewiring degron network	0.2222
p.Q498R	MZ7-mel	skin	COSMIC	PPGY	ITCH	502:505	Mutation rewiring degron network	0.2222
p.V496I	SIDM00609	Kidney Carcinoma	GDSC	PPGY	ITCH	502:505	Mutation rewiring degron network	0.1667
p.V496I	SIDM01619	Endometrial Carcinoma	GDSC	PPGY	ITCH	502:505	Mutation rewiring degron network	0.1667
p.V496I	ACH-000250	Kidney Cancer	CCLE	PPGY	ITCH	502:505	Mutation rewiring degron network	0.1667
p.V496I	ACH-000984	Endometrial/Uterine Cancer	CCLE	PPGY	ITCH	502:505	Mutation rewiring degron network	0.1667
p.V496I	KMRC-20	kidney	COSMIC	PPGY	ITCH	502:505	Mutation rewiring degron network	0.1667
p.G1371E	SIDM00225	Melanoma	GDSC	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.6087
p.G1371E	ACH-002143	Skin Cancer	CCLE	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.6087
p.G1371E	IST-MEL1	skin	COSMIC	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.6087
p.E1347G	SIDM01574	Plasma Cell Myeloma	GDSC	AGSSS	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.3056
p.E1347G	ACH-000588	Myeloma	CCLE	AGSSS	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.3056

Kaplan plot for TRPM7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRPM7

UniProt ID: Q96QT4

Entrez ID: 54822

Protein name: Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRPM7 in