DegronMD - Q96QT4(TRPM7)

FUNCTION: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating ca... View more >>

GO - Biological processes (BP): actomyosin structure organization [GO:0031032]; calcium-dependent cell-matrix adhesion [GO:0016340]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cation transmembrane transport [GO:0098655]; cellular magnesium ion homeostasis [GO:0010961]; divalent inorganic ... View more >>

GO - Molecular function (MF): actin binding [GO:0003779]; ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; cation channel activity [GO:0005261]; metal ion binding [GO:0046872]; myosin binding [GO:0017022]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein serine/threonine kinase activity [GO... View more >>

GO - Cellular component (CC): integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ruffle [GO:0001726]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1830M	TCGA-A5-A0G2	UCEC	TCGA	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	1826:1833	Mutation altering degron motif	0.8534
p.T1830M	TCGA-VQ-A8PT	STAD	TCGA	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	1826:1833	Mutation altering degron motif	0.8534
p.T1829M	DO51776	STAD	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	1826:1833	Mutation altering degron motif	0.7423
p.T1829M	DO41235	UCEC	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	1826:1833	Mutation altering degron motif	0.7423
p.R1366Q	TCGA-AP-A1DV	UCEC	TCGA	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.7329
p.R1366Q	TCGA-EI-6917	READ	TCGA	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.7329
p.R1366Q	DO36881	READ	ICGC	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.7329
p.R1366Q	DO43186	UCEC	ICGC	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.7329
p.Q1567K	DO229031	LICA	ICGC	ERNNLMRLS	DEG_APCC_DBOX_1	1559:1567	Mutation altering degron motif	0.6944
p.D1831N	DO222744	ESCA	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	1826:1833	Mutation altering degron motif	0.6932
p.P502S	TCGA-90-A4ED	LUSC	TCGA	PPGY	ITCH	502:505	Mutation altering degron motif	0.6752
p.P502S	DO45482	LUSC	ICGC	PPGY	ITCH	502:505	Mutation altering degron motif	0.6752
p.P502S	DO218906	SKCA	ICGC	PPGY	ITCH	502:505	Mutation altering degron motif	0.6752
p.Q1367H	TCGA-B5-A11E	UCEC	TCGA	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.647
p.Q1367H	DO41644	UCEC	ICGC	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.647
p.G1371E	SIDM00225	Melanoma	GDSC	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.6087
p.G1371E	ACH-002143	Skin Cancer	CCLE	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.6087
p.G1371E	IST-MEL1	skin	COSMIC	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.6087
p.E1373Q	DO222437	ESCA	ICGC	LRQRLHGVE	DEG_APCC_DBOX_1	1365:1373	Mutation altering degron motif	0.5633
p.V1558M	TCGA-AA-3861	COAD	TCGA	ERNNLMRLS	DEG_APCC_DBOX_1	1559:1567	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 67 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRPM7

UniProt ID: Q96QT4

Entrez ID: 54822

Protein name: Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRPM7 in