DegronMD

Uniprot ID: Q96QT4

Source protein: Transient receptor potential cation channel subfamily M member 7

Source gene: TRPM7

Class: DEG_SCF_SKP2-CKS1_1

Location: 1826:1833

E3 ligase: SKP2,CSK1

DEGRON score: 0.8737

ASA_SCORE: 80.0125

COIL: 0.731

CONS_SCORE: 0.1829

DSS_SCORE: 0.4685

HELIX: 0.2255

FCONS_SCORE: 0.7106

RIG_SCORE: 0.753

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1830M	TCGA-A5-A0G2	UCEC	TCGA	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	0.8534
p.T1830M	TCGA-VQ-A8PT	STAD	TCGA	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	0.8534
p.D1839Y	TCGA-EE-A17Z	SKCM	TCGA	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P1837H	TCGA-EE-A181	SKCM	TCGA	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	0.2222
p.D1831N	DO222744	ESCA	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	0.6932
p.P1840T	DO229019	LICA	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	0.1389
p.P1836S	DO222546	MELA	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	0.25
p.P1836H	DO37444	SKCM	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	0.25
p.D1838Y	DO37921	SKCM	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	0.1944
p.T1829M	DO51776	STAD	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	0.7423
p.T1829M	DO41235	UCEC	ICGC	RNDYTPDK	DEG_SCF_SKP2-CKS1_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QT4	Transient receptor potential cation channel subfamily M member 7	DEG_SCF_SKP2-CKS1_1	1826:1833	RNDYTPDK	SKP2,CSK1	0.8737	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons