DegronMD

Uniprot ID: Q96QT4

Source protein: Transient receptor potential cation channel subfamily M member 7

Source gene: TRPM7

Class: DEG_APCC_DBOX_1

Location: 1559:1567

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8996

ASA_SCORE: 76.6111

COIL: 0.4291

CONS_SCORE: 0.3229

DSS_SCORE: 0.2902

HELIX: 0.4823

FCONS_SCORE: 0.9968

RIG_SCORE: 0.7913

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1558M	TCGA-AA-3861	COAD	TCGA	ERNNLMRLS	DEG_APCC_DBOX_1	0.3056
p.Y1555C	TCGA-F7-A624	HNSC	TCGA	ERNNLMRLS	DEG_APCC_DBOX_1	0.2222
p.V1557M	DO9562	COAD	ICGC	ERNNLMRLS	DEG_APCC_DBOX_1	0.2778
p.Y1554C	DO44440	HNSC	ICGC	ERNNLMRLS	DEG_APCC_DBOX_1	0.1944
p.Y1554C	DO230976	LUSC	ICGC	ERNNLMRLS	DEG_APCC_DBOX_1	0.1944
p.Y1554C	DO224626	LUSC	ICGC	ERNNLMRLS	DEG_APCC_DBOX_1	0.1944
p.P1570Q	DO229019	LICA	ICGC	ERNNLMRLS	DEG_APCC_DBOX_1	0.25
p.Q1567K	DO229031	LICA	ICGC	ERNNLMRLS	DEG_APCC_DBOX_1	0.6944
p.T1550K	DO229037	LICA	ICGC	ERNNLMRLS	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QT4	Transient receptor potential cation channel subfamily M member 7	DEG_APCC_DBOX_1	1559:1567	ERNNLMRLS	APC,CDC20,FZR1	0.8996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons