DegronMD

Uniprot ID: Q96QT4

Source protein: Transient receptor potential cation channel subfamily M member 7

Source gene: TRPM7

Class: DEG_APCC_DBOX_1

Location: 1365:1373

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8551

ASA_SCORE: 88.9778

COIL: 0.4827

CONS_SCORE: 0.2824

DSS_SCORE: 0.3658

HELIX: 0.462

FCONS_SCORE: 1.016

RIG_SCORE: 0.7844

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1366Q	TCGA-AP-A1DV	UCEC	TCGA	LRQRLHGVE	DEG_APCC_DBOX_1	0.7329
p.R1366Q	TCGA-EI-6917	READ	TCGA	LRQRLHGVE	DEG_APCC_DBOX_1	0.7329
p.R1366Q	DO36881	READ	ICGC	LRQRLHGVE	DEG_APCC_DBOX_1	0.7329
p.R1366Q	DO43186	UCEC	ICGC	LRQRLHGVE	DEG_APCC_DBOX_1	0.7329
p.Q1367H	TCGA-B5-A11E	UCEC	TCGA	LRQRLHGVE	DEG_APCC_DBOX_1	0.647
p.Q1367H	DO41644	UCEC	ICGC	LRQRLHGVE	DEG_APCC_DBOX_1	0.647
p.P1357S	TCGA-BF-A5ER	SKCM	TCGA	LRQRLHGVE	DEG_APCC_DBOX_1	0.1111
p.P1357S	DO219454	SKCM	ICGC	LRQRLHGVE	DEG_APCC_DBOX_1	0.1111
p.E1373Q	DO222437	ESCA	ICGC	LRQRLHGVE	DEG_APCC_DBOX_1	0.5633
p.P1362S	SIDM00197	Ewing's Sarcoma	GDSC	LRQRLHGVE	DEG_APCC_DBOX_1	0.25
p.P1362S	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	LRQRLHGVE	DEG_APCC_DBOX_1	0.25
p.P1362S	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	LRQRLHGVE	DEG_APCC_DBOX_1	0.25
p.G1371E	SIDM00225	Melanoma	GDSC	LRQRLHGVE	DEG_APCC_DBOX_1	0.6087
p.G1371E	ACH-002143	Skin Cancer	CCLE	LRQRLHGVE	DEG_APCC_DBOX_1	0.6087
p.G1371E	IST-MEL1	skin	COSMIC	LRQRLHGVE	DEG_APCC_DBOX_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QT4	Transient receptor potential cation channel subfamily M member 7	DEG_APCC_DBOX_1	1365:1373	LRQRLHGVE	APC,CDC20,FZR1	0.8551	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons