DegronMD - Q6UXY8(TMC5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A199T	TCGA-A3-3349	KIRC	TCGA	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.6028
p.A199T	TCGA-A5-A0G2	UCEC	TCGA	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.6028
p.A199T	TCGA-D5-6930	COAD	TCGA	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.6028
p.A199T	DO10550	COAD	ICGC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.6028
p.A199T	DO20614	KIRC	ICGC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.6028
p.A199T	DO41235	UCEC	ICGC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.6028
p.R133Q	TCGA-A5-A0G2	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1944
p.R133Q	TCGA-AX-A05Z	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1944
p.R133Q	TCGA-EB-A97M	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1944
p.R133Q	TCGA-ER-A19O	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1944
p.R133Q	TCGA-FS-A1ZW	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1944
p.R133Q	TCGA-GN-A26C	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1944
p.R133Q	DO220885	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1944
p.R133Q	DO37519	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1944
p.R133Q	DO37782	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1944
p.R133Q	DO50298	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1944
p.R133Q	DO38063	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1944
p.R133Q	DO40884	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1944
p.R133Q	DO41235	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1944
p.R194I	TCGA-A5-A2K5	UCEC	TCGA	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.3056
p.R194I	DO41379	UCEC	ICGC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.3056
p.K186N	TCGA-AG-3892	READ	TCGA	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation substituting flanking lysine	0.1944
p.K186N	TCGA-AX-A06F	UCEC	TCGA	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation substituting flanking lysine	0.1944
p.K186N	DO36394	READ	ICGC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation substituting flanking lysine	0.1944
p.K186N	DO41752	UCEC	ICGC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation substituting flanking lysine	0.1944
p.H190R	TCGA-BR-8485	STAD	TCGA	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1944
p.H190R	DO47823	STAD	ICGC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1944
p.G203E	TCGA-EE-A29E	SKCM	TCGA	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.25
p.G203E	TCGA-EE-A29L	SKCM	TCGA	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.25
p.G203E	DO222599	MELA	ICGC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.25
p.G203E	DO37835	SKCM	ICGC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.25
p.G203E	DO37831	SKCM	ICGC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.25
p.G203R	TCGA-EE-A29S	SKCM	TCGA	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.25
p.G203R	DO37936	SKCM	ICGC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.25
p.P135S	TCGA-EE-A3AG	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.P135S	DO37471	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.P135L	TCGA-EE-A3JD	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.P135L	DO50299	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.P135L	SIDM00140	Melanoma	GDSC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.P135L	ACH-000968	Skin Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.P135L	COLO-792	skin	COSMIC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.P197L	TCGA-FW-A3R5	SKCM	TCGA	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.6471
p.P197L	DO37406	SKCM	ICGC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.6471
p.G130E	TCGA-FW-A3TU	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1111
p.G130E	DO37441	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1111
p.E132D	DO48566	BLCA	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1667
p.R150G	DO49797	BLCA	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1111
p.P129S	DO222404	BTCA	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0833
p.K144N	DO223732	CESC	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2778
p.R150I	DO8264	COAD	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1111
p.Q186R	DO17216	KIRC	ICGC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation substituting flanking lysine	0.1944
p.Q147H	DO44513	KIRP	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1944
p.S142C	DO228188	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7541
p.I139L	DO228972	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7174
p.R137G	DO52326	LIHC	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.3056
p.R128K	DO222847	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation blocking phosphorylation signal	0.5
p.R128K	DO37406	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation blocking phosphorylation signal	0.5
p.R150C	DO47284	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1111
p.R150C	DO37450	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1111
p.R137M	DO39421	THCA	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.3056
p.V200I	DO42256	UCEC	ICGC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.7076
p.V200I	DO42681	UCEC	ICGC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.7076
p.D141G	DO42568	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7198
p.E189K	SIDM00955	Melanoma	GDSC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1667
p.E189K	ACH-000812	Skin Cancer	CCLE	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1667
p.E189K	COLO-783	skin	COSMIC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1667
p.S140F	SIDM00189	Melanoma	GDSC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7982
p.S140F	ACH-002098	Skin Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7982
p.S140F	CP67-MEL	skin	COSMIC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7982
p.D200N	ACH-001648	Prostate Cancer	CCLE	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.6932
p.G202R	SCC-15	upper aerodigestive tract	COSMIC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.2778
p.L130F	SW684	soft tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1111
p.W185C	CHSA8926	bone	COSMIC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.0556
p.L201F	SW684	soft tissue	COSMIC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.3056
p.G204R	SK-MEL-5	skin	COSMIC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation substituting flanking lysine	0.3333
p.L149Q	COR-L303	lung	COSMIC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1389
p.I192T	CAL-39	vulva	COSMIC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation blocking phosphorylation signal	0.6944
p.T188M	H2722	pleura	COSMIC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1389
p.L209P	SNU-C2B	large intestine	COSMIC	INPYAD	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMC5

UniProt ID: Q6UXY8

Entrez ID: 79838

Protein name: Transmembrane channel-like protein 5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMC5 in