DegronMD

Uniprot ID: Q6UXY8

Source protein: Transmembrane channel-like protein 5

Source gene: TMC5

Class: LIG_APCC_ABBA_1

Location: 195:200

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9964

ASA_SCORE: 81.8

COIL: 0.912

CONS_SCORE: 0.293

DSS_SCORE: 0.5736

HELIX: 0.0607

FCONS_SCORE: 0.9062

RIG_SCORE: 0.7042

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A199T	TCGA-A3-3349	KIRC	TCGA	INPYAD	LIG_APCC_ABBA_1	0.6028
p.A199T	TCGA-A5-A0G2	UCEC	TCGA	INPYAD	LIG_APCC_ABBA_1	0.6028
p.A199T	TCGA-D5-6930	COAD	TCGA	INPYAD	LIG_APCC_ABBA_1	0.6028
p.A199T	DO10550	COAD	ICGC	INPYAD	LIG_APCC_ABBA_1	0.6028
p.A199T	DO20614	KIRC	ICGC	INPYAD	LIG_APCC_ABBA_1	0.6028
p.A199T	DO41235	UCEC	ICGC	INPYAD	LIG_APCC_ABBA_1	0.6028
p.R194I	TCGA-A5-A2K5	UCEC	TCGA	INPYAD	LIG_APCC_ABBA_1	0.3056
p.R194I	DO41379	UCEC	ICGC	INPYAD	LIG_APCC_ABBA_1	0.3056
p.K186N	TCGA-AG-3892	READ	TCGA	INPYAD	LIG_APCC_ABBA_1	0.1944
p.K186N	TCGA-AX-A06F	UCEC	TCGA	INPYAD	LIG_APCC_ABBA_1	0.1944
p.K186N	DO36394	READ	ICGC	INPYAD	LIG_APCC_ABBA_1	0.1944
p.K186N	DO41752	UCEC	ICGC	INPYAD	LIG_APCC_ABBA_1	0.1944
p.H190R	TCGA-BR-8485	STAD	TCGA	INPYAD	LIG_APCC_ABBA_1	0.1944
p.H190R	DO47823	STAD	ICGC	INPYAD	LIG_APCC_ABBA_1	0.1944
p.G203E	TCGA-EE-A29E	SKCM	TCGA	INPYAD	LIG_APCC_ABBA_1	0.25
p.G203E	TCGA-EE-A29L	SKCM	TCGA	INPYAD	LIG_APCC_ABBA_1	0.25
p.G203E	DO222599	MELA	ICGC	INPYAD	LIG_APCC_ABBA_1	0.25
p.G203E	DO37835	SKCM	ICGC	INPYAD	LIG_APCC_ABBA_1	0.25
p.G203E	DO37831	SKCM	ICGC	INPYAD	LIG_APCC_ABBA_1	0.25
p.G203R	TCGA-EE-A29S	SKCM	TCGA	INPYAD	LIG_APCC_ABBA_1	0.25
p.G203R	DO37936	SKCM	ICGC	INPYAD	LIG_APCC_ABBA_1	0.25
p.P197L	TCGA-FW-A3R5	SKCM	TCGA	INPYAD	LIG_APCC_ABBA_1	0.6471
p.P197L	DO37406	SKCM	ICGC	INPYAD	LIG_APCC_ABBA_1	0.6471
p.Q186R	DO17216	KIRC	ICGC	INPYAD	LIG_APCC_ABBA_1	0.1944
p.V200I	DO42256	UCEC	ICGC	INPYAD	LIG_APCC_ABBA_1	0.7076
p.V200I	DO42681	UCEC	ICGC	INPYAD	LIG_APCC_ABBA_1	0.7076
p.E189K	SIDM00955	Melanoma	GDSC	INPYAD	LIG_APCC_ABBA_1	0.1667
p.E189K	ACH-000812	Skin Cancer	CCLE	INPYAD	LIG_APCC_ABBA_1	0.1667
p.E189K	COLO-783	skin	COSMIC	INPYAD	LIG_APCC_ABBA_1	0.1667
p.D200N	ACH-001648	Prostate Cancer	CCLE	INPYAD	LIG_APCC_ABBA_1	0.6932
p.G202R	SCC-15	upper_aerodigestive_tract	COSMIC	INPYAD	LIG_APCC_ABBA_1	0.2778
p.W185C	CHSA8926	bone	COSMIC	INPYAD	LIG_APCC_ABBA_1	0.0556
p.L201F	SW684	soft_tissue	COSMIC	INPYAD	LIG_APCC_ABBA_1	0.3056
p.G204R	SK-MEL-5	skin	COSMIC	INPYAD	LIG_APCC_ABBA_1	0.3333
p.I192T	CAL-39	vulva	COSMIC	INPYAD	LIG_APCC_ABBA_1	0.6944
p.T188M	H2722	pleura	COSMIC	INPYAD	LIG_APCC_ABBA_1	0.1389
p.L209P	SNU-C2B	large_intestine	COSMIC	INPYAD	LIG_APCC_ABBA_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: INPYAD

Degron related mutations and impact score

Drug responses associated with TMC5 mutations

All proteins holding degron of INPYAD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UXY8	Transmembrane channel-like protein 5	LIG_APCC_ABBA_1	195:200	INPYAD	APC,CDC20,FZR1	0.9964	More...