DegronMD - Q9P267(MBD5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q1113P	TCGA-2H-A9GL	ESCA	TCGA	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.3056
p.P1061L	TCGA-50-6590	LUAD	TCGA	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation rewiring degron network	0.1389
p.S537C	TCGA-78-7161	LUAD	TCGA	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.0833
p.S537C	DO25975	LUAD	ICGC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.0833
p.F541I	TCGA-AG-A036	READ	TCGA	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.1944
p.F541I	DO37245	READ	ICGC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.1944
p.G547V	TCGA-AR-A0TZ	BRCA	TCGA	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.6421
p.G547V	DO2287	BRCA	ICGC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.6421
p.L1049P	TCGA-D1-A16X	UCEC	TCGA	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation altering degron motif	0.7582
p.L1049R	TCGA-D9-A6EC	SKCM	TCGA	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation altering degron motif	0.8428
p.P1042S	TCGA-DA-A1I7	SKCM	TCGA	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation rewiring degron network	0.1389
p.P1045L	TCGA-EE-A29E	SKCM	TCGA	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation rewiring degron network	0.2222
p.P1045L	DO37831	SKCM	ICGC	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation rewiring degron network	0.2222
p.P536T	TCGA-GN-A26C	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.0556
p.P536T	DO37782	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.0556
p.P536T	SIDM00217	Colorectal Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.0556
p.P536T	ACH-000999	Colon/Colorectal Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.0556
p.P536T	SNU-1040	large intestine	COSMIC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.0556
p.A544V	DO225337	BRCA	ICGC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.2778
p.G1055W	DO8914	COAD	ICGC	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation rewiring degron network	0.3056
p.S548R	DO234233	ESAD	ICGC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.7427
p.S1060I	DO229041	LICA	ICGC	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation rewiring degron network	0.1667
p.V551L	DO222557	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.3056
p.I1104V	SIDM00557	Neuroblastoma	GDSC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.2222
p.I1104V	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.2222
p.I1104V	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.2222
p.I1104V	SIDM00489	Oral Cavity Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.2222
p.I1104V	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.2222
p.I1104V	SIDM00163	Biliary Tract Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.2222
p.T1048I	SIDM00222	Mesothelioma	GDSC	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation rewiring degron network	0.3056
p.S545P	SIDM00845	Burkitt's Lymphoma	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.3056
p.S545P	SIDM00035	Thyroid Gland Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.3056
p.S545P	SIDM00461	Acute Myeloid Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.3056
p.S545P	SIDM00946	T-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.3056
p.S545P	SIDM01519	Head and Neck Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.3056
p.S545P	ACH-000786	Lymphoma	CCLE	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.3056
p.S545P	ACH-000992	Head and Neck Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.3056
p.S545P	ACH-001067	Brain Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.3056
p.S545P	DND-41	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.3056
p.S545P	S-117	soft tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.3056
p.S545P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.3056
p.S545P	Daudi	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.3056
p.S548N	SIDM00845	Burkitt's Lymphoma	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.7069
p.S548N	SIDM00035	Thyroid Gland Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.7069
p.S548N	SIDM00461	Acute Myeloid Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.7069
p.S548N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.7069
p.S548N	SIDM01519	Head and Neck Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.7069
p.S548N	ACH-000786	Lymphoma	CCLE	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.7069
p.S548N	ACH-000992	Head and Neck Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.7069
p.S548N	Daudi	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.7069
p.S548N	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.7069
p.S548N	DND-41	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.7069
p.S548N	S-117	soft tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.7069
p.S549G	SIDM00845	Burkitt's Lymphoma	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.6993
p.S549G	SIDM00035	Thyroid Gland Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.6993
p.S549G	SIDM00461	Acute Myeloid Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.6993
p.S549G	SIDM00946	T-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.6993
p.S549G	SIDM01519	Head and Neck Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.6993
p.S549G	ACH-000786	Lymphoma	CCLE	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.6993
p.S549G	ACH-000992	Head and Neck Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.6993
p.S549G	DND-41	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.6993
p.S549G	Daudi	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.6993
p.S549G	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.6993
p.S549G	S-117	soft tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.6993
p.T1106A	SIDM00535	Chondrosarcoma	GDSC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.2778
p.T1106A	ACH-001519	Bone Cancer	CCLE	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.2778
p.T1106A	H-EMC-SS	bone	COSMIC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.2778
p.T1047S	SIDM00789	Colorectal Carcinoma	GDSC	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation rewiring degron network	0.2778
p.T1047S	ACH-000997	Colon/Colorectal Cancer	CCLE	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation rewiring degron network	0.2778
p.T1047S	HCT-15	large intestine	COSMIC	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation rewiring degron network	0.2778
p.G547R	SIDM00447	B-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.6457
p.G547R	ACH-000960	Leukemia	CCLE	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.6457
p.P1118Q	SIDM01193	Glioma	GDSC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.1667
p.P1118Q	ACH-000040	Brain Cancer	CCLE	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.1667
p.P1118Q	U-118-MG	central nervous system	COSMIC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.1667
p.M1100I	SIDM00217	Colorectal Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.1111
p.M1100I	ACH-000999	Colon/Colorectal Cancer	CCLE	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.1111
p.M1100I	SNU-1040	large intestine	COSMIC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.1111
p.G1099E	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.0833
p.G1099E	ACH-000869	Lung Cancer	CCLE	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.0833
p.G1099E	NCI-H1568	lung	COSMIC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.0833
p.P1116L	SIDM01612	Endometrial Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.2222
p.P1116L	ACH-000946	Endometrial/Uterine Cancer	CCLE	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.2222
p.P536A	SIDM01336	Glioblastoma	GDSC	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.0556
p.P536A	ACH-000368	Brain Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.0556
p.A1107V	SIDM01619	Endometrial Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.3056
p.A1107V	ACH-000984	Endometrial/Uterine Cancer	CCLE	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.3056
p.Q1101H	ACH-001484	Leukemia	CCLE	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.1389
p.Q1101H	ACH-001485	Leukemia	CCLE	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.1389
p.E1047D	Daudi	haematopoietic and lymphoid tissue	COSMIC	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation rewiring degron network	0.2778
p.Q1114H	NCI-H1651	lung	COSMIC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.2778
p.L1049I	KM12	large intestine	COSMIC	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation altering degron motif	0.6063
p.L1049I	NCI-H520	lung	COSMIC	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation altering degron motif	0.6063
p.L1049I	NB12	autonomic ganglia	COSMIC	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation altering degron motif	0.6063
p.N1103I	Daudi	haematopoietic and lymphoid tissue	COSMIC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.1944
p.N1103I	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.1944
p.N1103I	S-117	soft tissue	COSMIC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.1944
p.N1103I	DND-41	haematopoietic and lymphoid tissue	COSMIC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation rewiring degron network	0.1944
p.P1057L	MEL-JUSO	skin	COSMIC	LPPFQD	LIG_APCC_ABBA_1	1049:1054	Mutation rewiring degron network	0.25
p.A1110T	KM12	large intestine	COSMIC	VNSTT	DEG_SPOP_SBC_1	1108:1112	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MBD5

UniProt ID: Q9P267

Entrez ID: 55777

Protein name: Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MBD5 in