DegronMD

Uniprot ID: Q9P267

Source protein: Methyl-CpG-binding domain protein 5

Source gene: MBD5

Class: LIG_APCC_ABBA_1

Location: 1049:1054

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9949

ASA_SCORE: 93.1167

COIL: 0.9313

CONS_SCORE: 0.3837

DSS_SCORE: 0.6843

HELIX: 0.0343

FCONS_SCORE: 1.2372

RIG_SCORE: 0.7168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1061L	TCGA-50-6590	LUAD	TCGA	LPPFQD	LIG_APCC_ABBA_1	0.1389
p.L1049P	TCGA-D1-A16X	UCEC	TCGA	LPPFQD	LIG_APCC_ABBA_1	0.7582
p.L1049R	TCGA-D9-A6EC	SKCM	TCGA	LPPFQD	LIG_APCC_ABBA_1	0.8428
p.P1042S	TCGA-DA-A1I7	SKCM	TCGA	LPPFQD	LIG_APCC_ABBA_1	0.1389
p.P1045L	TCGA-EE-A29E	SKCM	TCGA	LPPFQD	LIG_APCC_ABBA_1	0.2222
p.P1045L	DO37831	SKCM	ICGC	LPPFQD	LIG_APCC_ABBA_1	0.2222
p.G1055W	DO8914	COAD	ICGC	LPPFQD	LIG_APCC_ABBA_1	0.3056
p.S1060I	DO229041	LICA	ICGC	LPPFQD	LIG_APCC_ABBA_1	0.1667
p.T1048I	SIDM00222	Mesothelioma	GDSC	LPPFQD	LIG_APCC_ABBA_1	0.3056
p.T1047S	SIDM00789	Colorectal Carcinoma	GDSC	LPPFQD	LIG_APCC_ABBA_1	0.2778
p.T1047S	ACH-000997	Colon/Colorectal Cancer	CCLE	LPPFQD	LIG_APCC_ABBA_1	0.2778
p.T1047S	HCT-15	large_intestine	COSMIC	LPPFQD	LIG_APCC_ABBA_1	0.2778
p.E1047D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LPPFQD	LIG_APCC_ABBA_1	0.2778
p.L1049I	KM12	large_intestine	COSMIC	LPPFQD	LIG_APCC_ABBA_1	0.6063
p.L1049I	NCI-H520	lung	COSMIC	LPPFQD	LIG_APCC_ABBA_1	0.6063
p.L1049I	NB12	autonomic_ganglia	COSMIC	LPPFQD	LIG_APCC_ABBA_1	0.6063
p.P1057L	MEL-JUSO	skin	COSMIC	LPPFQD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P267	Methyl-CpG-binding domain protein 5	LIG_APCC_ABBA_1	1049:1054	LPPFQD	APC,CDC20,FZR1	0.9949	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons