DegronMD

Uniprot ID: Q9P267

Source protein: Methyl-CpG-binding domain protein 5

Source gene: MBD5

Class: DEG_SPOP_SBC_1

Location: 1108:1112

E3 ligase: SPOP

DEGRON score: 0.5045

ASA_SCORE: 92.38

COIL: 0.928

CONS_SCORE: 0.4301

DSS_SCORE: 0.1552

HELIX: 0.0272

FCONS_SCORE: 0.8963

RIG_SCORE: 0.811

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1113P	TCGA-2H-A9GL	ESCA	TCGA	VNSTT	DEG_SPOP_SBC_1	0.3056
p.I1104V	SIDM00557	Neuroblastoma	GDSC	VNSTT	DEG_SPOP_SBC_1	0.2222
p.I1104V	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VNSTT	DEG_SPOP_SBC_1	0.2222
p.I1104V	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	0.2222
p.I1104V	SIDM00489	Oral Cavity Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	0.2222
p.I1104V	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	0.2222
p.I1104V	SIDM00163	Biliary Tract Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	0.2222
p.T1106A	SIDM00535	Chondrosarcoma	GDSC	VNSTT	DEG_SPOP_SBC_1	0.2778
p.T1106A	ACH-001519	Bone Cancer	CCLE	VNSTT	DEG_SPOP_SBC_1	0.2778
p.T1106A	H-EMC-SS	bone	COSMIC	VNSTT	DEG_SPOP_SBC_1	0.2778
p.P1118Q	SIDM01193	Glioma	GDSC	VNSTT	DEG_SPOP_SBC_1	0.1667
p.P1118Q	ACH-000040	Brain Cancer	CCLE	VNSTT	DEG_SPOP_SBC_1	0.1667
p.P1118Q	U-118-MG	central_nervous_system	COSMIC	VNSTT	DEG_SPOP_SBC_1	0.1667
p.M1100I	SIDM00217	Colorectal Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	0.1111
p.M1100I	ACH-000999	Colon/Colorectal Cancer	CCLE	VNSTT	DEG_SPOP_SBC_1	0.1111
p.M1100I	SNU-1040	large_intestine	COSMIC	VNSTT	DEG_SPOP_SBC_1	0.1111
p.G1099E	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	0.0833
p.G1099E	ACH-000869	Lung Cancer	CCLE	VNSTT	DEG_SPOP_SBC_1	0.0833
p.G1099E	NCI-H1568	lung	COSMIC	VNSTT	DEG_SPOP_SBC_1	0.0833
p.P1116L	SIDM01612	Endometrial Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	0.2222
p.P1116L	ACH-000946	Endometrial/Uterine Cancer	CCLE	VNSTT	DEG_SPOP_SBC_1	0.2222
p.A1107V	SIDM01619	Endometrial Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	0.3056
p.A1107V	ACH-000984	Endometrial/Uterine Cancer	CCLE	VNSTT	DEG_SPOP_SBC_1	0.3056
p.Q1101H	ACH-001484	Leukemia	CCLE	VNSTT	DEG_SPOP_SBC_1	0.1389
p.Q1101H	ACH-001485	Leukemia	CCLE	VNSTT	DEG_SPOP_SBC_1	0.1389
p.Q1114H	NCI-H1651	lung	COSMIC	VNSTT	DEG_SPOP_SBC_1	0.2778
p.N1103I	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VNSTT	DEG_SPOP_SBC_1	0.1944
p.N1103I	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VNSTT	DEG_SPOP_SBC_1	0.1944
p.N1103I	S-117	soft_tissue	COSMIC	VNSTT	DEG_SPOP_SBC_1	0.1944
p.N1103I	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VNSTT	DEG_SPOP_SBC_1	0.1944
p.A1110T	KM12	large_intestine	COSMIC	VNSTT	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07996	Thrombospondin-1	DEG_SPOP_SBC_1	1066:1070	VNSTT	SPOP	0.7365	More...
P35442	Thrombospondin-2	DEG_SPOP_SBC_1	1068:1072	VNSTT	SPOP	0.7159	More...
Q2KHM9	Protein moonraker	DEG_SPOP_SBC_1	698:702	VNSTT	SPOP	0.9076	More...
Q9P267	Methyl-CpG-binding domain protein 5	DEG_SPOP_SBC_1	1108:1112	VNSTT	SPOP	0.5045	More...
Q9Y4B6	DDB1- and CUL4-associated factor 1	DEG_SPOP_SBC_1	253:257	VNSTT	SPOP	0.9891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VNSTT

Degron related mutations and impact score

Drug responses associated with MBD5 mutations

All proteins holding degron of VNSTT