DegronMD

Uniprot ID: P07996

Source protein: Thrombospondin-1

Source gene: THBS1

Class: DEG_SPOP_SBC_1

Location: 1066:1070

E3 ligase: SPOP

DEGRON score: 0.7365

ASA_SCORE: 54.4

COIL: 0.7318

CONS_SCORE: 0.8568

DSS_SCORE: 0.4414

HELIX: 0.0086

FCONS_SCORE: 1.1337

RIG_SCORE: 0.6971

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1072T	TCGA-36-2533	OV	TCGA	VNSTT	DEG_SPOP_SBC_1	0.2778
p.P1072T	DO32516	OV	ICGC	VNSTT	DEG_SPOP_SBC_1	0.2778
p.R1077W	TCGA-A5-A0VQ	UCEC	TCGA	VNSTT	DEG_SPOP_SBC_1	0.1389
p.R1077W	TCGA-AN-A0AK	BRCA	TCGA	VNSTT	DEG_SPOP_SBC_1	0.1389
p.R1077W	TCGA-G4-6309	COAD	TCGA	VNSTT	DEG_SPOP_SBC_1	0.1389
p.R1077W	DO1608	BRCA	ICGC	VNSTT	DEG_SPOP_SBC_1	0.1389
p.R1077W	DO7810	COAD	ICGC	VNSTT	DEG_SPOP_SBC_1	0.1389
p.R1077W	DO42113	UCEC	ICGC	VNSTT	DEG_SPOP_SBC_1	0.1389
p.P1072H	TCGA-AA-3949	COAD	TCGA	VNSTT	DEG_SPOP_SBC_1	0.2778
p.P1072H	DO7798	COAD	ICGC	VNSTT	DEG_SPOP_SBC_1	0.2778
p.A1079T	TCGA-CG-5725	STAD	TCGA	VNSTT	DEG_SPOP_SBC_1	0.0833
p.A1079T	DO38191	STAD	ICGC	VNSTT	DEG_SPOP_SBC_1	0.0833
p.G1057E	TCGA-D3-A51R	SKCM	TCGA	VNSTT	DEG_SPOP_SBC_1	0.0833
p.G1057E	DO47480	SKCM	ICGC	VNSTT	DEG_SPOP_SBC_1	0.0833
p.R1077Q	TCGA-DX-A6BF	SARC	TCGA	VNSTT	DEG_SPOP_SBC_1	0.1389
p.R1077Q	DO219998	SARC	ICGC	VNSTT	DEG_SPOP_SBC_1	0.1389
p.L1061P	TCGA-IZ-8195	KIRP	TCGA	VNSTT	DEG_SPOP_SBC_1	0.1944
p.L1061P	DO44471	KIRP	ICGC	VNSTT	DEG_SPOP_SBC_1	0.1944
p.G1060S	DO220852	MELA	ICGC	VNSTT	DEG_SPOP_SBC_1	0.1667
p.E1074K	ACH-000687	Lymphoma	CCLE	VNSTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07996	Thrombospondin-1	DEG_SPOP_SBC_1	1066:1070	VNSTT	SPOP	0.7365	More...
P35442	Thrombospondin-2	DEG_SPOP_SBC_1	1068:1072	VNSTT	SPOP	0.7159	More...
Q2KHM9	Protein moonraker	DEG_SPOP_SBC_1	698:702	VNSTT	SPOP	0.9076	More...
Q9P267	Methyl-CpG-binding domain protein 5	DEG_SPOP_SBC_1	1108:1112	VNSTT	SPOP	0.5045	More...
Q9Y4B6	DDB1- and CUL4-associated factor 1	DEG_SPOP_SBC_1	253:257	VNSTT	SPOP	0.9891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons