DegronMD

Uniprot ID: P35442

Source protein: Thrombospondin-2

Source gene: THBS2

Class: DEG_SPOP_SBC_1

Location: 1068:1072

E3 ligase: SPOP

DEGRON score: 0.7159

ASA_SCORE: 52.44

COIL: 0.7046

CONS_SCORE: 0.863

DSS_SCORE: 0.3687

HELIX: 0.0124

FCONS_SCORE: 1.1127

RIG_SCORE: 0.7358

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1074M	TCGA-AJ-A3BG	UCEC	TCGA	VNSTT	DEG_SPOP_SBC_1	0.2778
p.T1074M	DO42633	UCEC	ICGC	VNSTT	DEG_SPOP_SBC_1	0.2778
p.T1074S	TCGA-AZ-6598	COAD	TCGA	VNSTT	DEG_SPOP_SBC_1	0.2778
p.T1074S	DO10276	COAD	ICGC	VNSTT	DEG_SPOP_SBC_1	0.2778
p.S1061Y	TCGA-FI-A2D5	UCEC	TCGA	VNSTT	DEG_SPOP_SBC_1	0.1389
p.S1061Y	DO41331	UCEC	ICGC	VNSTT	DEG_SPOP_SBC_1	0.1389
p.S1064P	DO228581	GACA	ICGC	VNSTT	DEG_SPOP_SBC_1	0.2222
p.T1071N	DO229022	LICA	ICGC	VNSTT	DEG_SPOP_SBC_1	0.7055
p.A1081E	DO229038	LICA	ICGC	VNSTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07996	Thrombospondin-1	DEG_SPOP_SBC_1	1066:1070	VNSTT	SPOP	0.7365	More...
P35442	Thrombospondin-2	DEG_SPOP_SBC_1	1068:1072	VNSTT	SPOP	0.7159	More...
Q2KHM9	Protein moonraker	DEG_SPOP_SBC_1	698:702	VNSTT	SPOP	0.9076	More...
Q9P267	Methyl-CpG-binding domain protein 5	DEG_SPOP_SBC_1	1108:1112	VNSTT	SPOP	0.5045	More...
Q9Y4B6	DDB1- and CUL4-associated factor 1	DEG_SPOP_SBC_1	253:257	VNSTT	SPOP	0.9891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons