DegronMD

Uniprot ID: Q9Y4B6

Source protein: DDB1- and CUL4-associated factor 1

Source gene: DCAF1

Class: DEG_SPOP_SBC_1

Location: 253:257

E3 ligase: SPOP

DEGRON score: 0.9891

ASA_SCORE: 86.92

COIL: 0.9424

CONS_SCORE: 0.295

DSS_SCORE: 0.6763

HELIX: 0.024

FCONS_SCORE: 1.0289

RIG_SCORE: 0.6024

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D261G	SIDM00151	Ovarian Carcinoma	GDSC	VNSTT	DEG_SPOP_SBC_1	0.2222
p.D261G	IGROV-1	ovary	COSMIC	VNSTT	DEG_SPOP_SBC_1	0.2222
p.D260G	IGROV-1	ovary	COSMIC	VNSTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07996	Thrombospondin-1	DEG_SPOP_SBC_1	1066:1070	VNSTT	SPOP	0.7365	More...
P35442	Thrombospondin-2	DEG_SPOP_SBC_1	1068:1072	VNSTT	SPOP	0.7159	More...
Q2KHM9	Protein moonraker	DEG_SPOP_SBC_1	698:702	VNSTT	SPOP	0.9076	More...
Q9P267	Methyl-CpG-binding domain protein 5	DEG_SPOP_SBC_1	1108:1112	VNSTT	SPOP	0.5045	More...
Q9Y4B6	DDB1- and CUL4-associated factor 1	DEG_SPOP_SBC_1	253:257	VNSTT	SPOP	0.9891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons