DegronMD

Uniprot ID: Q2KHM9

Source protein: Protein moonraker

Source gene: KIAA0753

Class: DEG_SPOP_SBC_1

Location: 698:702

E3 ligase: SPOP

DEGRON score: 0.9076

ASA_SCORE: 86.14

COIL: 0.741

CONS_SCORE: 0.3343

DSS_SCORE: 0.3414

HELIX: 0.244

FCONS_SCORE: 0.9273

RIG_SCORE: 0.7269

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S700Y	TCGA-AX-A06F	UCEC	TCGA	VNSTT	DEG_SPOP_SBC_1	0.8231
p.L708F	TCGA-N9-A4Q7	UCS	TCGA	VNSTT	DEG_SPOP_SBC_1	0.1667
p.E703K	TCGA-W3-AA1V	SKCM	TCGA	VNSTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07996	Thrombospondin-1	DEG_SPOP_SBC_1	1066:1070	VNSTT	SPOP	0.7365	More...
P35442	Thrombospondin-2	DEG_SPOP_SBC_1	1068:1072	VNSTT	SPOP	0.7159	More...
Q2KHM9	Protein moonraker	DEG_SPOP_SBC_1	698:702	VNSTT	SPOP	0.9076	More...
Q9P267	Methyl-CpG-binding domain protein 5	DEG_SPOP_SBC_1	1108:1112	VNSTT	SPOP	0.5045	More...
Q9Y4B6	DDB1- and CUL4-associated factor 1	DEG_SPOP_SBC_1	253:257	VNSTT	SPOP	0.9891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons