DegronMD - P07996(THBS1)

GO - Biological processes (BP): behavioral response to pain [GO:0048266]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to growth factor stimulus [GO:0071363]; cellular response to heat [GO:0034605]; cellular response to tumor necrosis factor [GO:0071356]; chronic inflammatory response [GO:0002544]; engulfment of apoptotic cell [GO:0043652]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002581]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cGMP-mediated signaling [GO:0010754]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; negative regulation of nitric oxide mediated signal transduction [GO:0010751]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of sprouting angiogenesis [GO:1903671]; peptide cross-linking [GO:0018149]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of macrophage activation [GO:0043032]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transforming growth factor beta1 production [GO:0032914]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of translation [GO:0045727]; positive regulation of tumor necrosis factor production [GO:0032760]; response to calcium ion [GO:0051592]; response to endoplasmic reticulum stress [GO:0034976]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to magnesium ion [GO:0032026]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; response to unfolded protein [GO:0006986]; response to xenobiotic stimulus [GO:0009410]; sprouting angiogenesis [GO:0002040] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1072T	TCGA-36-2533	OV	TCGA	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.2778
p.P1072T	DO32516	OV	ICGC	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.2778
p.D924N	TCGA-A5-A0G9	UCEC	TCGA	DDFDHDSVPDI	DEG_COP1_1	932:942	Mutation rewiring degron network	0.1111
p.D924N	DO233120	GACA	ICGC	DDFDHDSVPDI	DEG_COP1_1	932:942	Mutation rewiring degron network	0.1111
p.D924N	DO42304	UCEC	ICGC	DDFDHDSVPDI	DEG_COP1_1	932:942	Mutation rewiring degron network	0.1111
p.D924N	SIDM00989	Bladder Carcinoma	GDSC	DDFDHDSVPDI	DEG_COP1_1	932:942	Mutation rewiring degron network	0.1111
p.D924N	ACH-000802	Bladder Cancer	CCLE	DDFDHDSVPDI	DEG_COP1_1	932:942	Mutation rewiring degron network	0.1111
p.D924N	BFTC-905	urinary tract	COSMIC	DDFDHDSVPDI	DEG_COP1_1	932:942	Mutation rewiring degron network	0.1111
p.R1077W	TCGA-A5-A0VQ	UCEC	TCGA	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.1389
p.R1077W	TCGA-AN-A0AK	BRCA	TCGA	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.1389
p.R1077W	TCGA-G4-6309	COAD	TCGA	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.1389
p.R1077W	DO1608	BRCA	ICGC	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.1389
p.R1077W	DO7810	COAD	ICGC	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.1389
p.R1077W	DO42113	UCEC	ICGC	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.1389
p.P1072H	TCGA-AA-3949	COAD	TCGA	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.2778
p.P1072H	DO7798	COAD	ICGC	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.2778
p.A1079T	TCGA-CG-5725	STAD	TCGA	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.0833
p.A1079T	DO38191	STAD	ICGC	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.0833
p.G1057E	TCGA-D3-A51R	SKCM	TCGA	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.0833
p.G1057E	DO47480	SKCM	ICGC	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.0833
p.R1077Q	TCGA-DX-A6BF	SARC	TCGA	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.1389
p.R1077Q	DO219998	SARC	ICGC	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.1389
p.D943E	TCGA-DX-A8BL	SARC	TCGA	DDFDHDSVPDI	DEG_COP1_1	932:942	Mutation rewiring degron network	0.3056
p.D943E	DO220049	SARC	ICGC	DDFDHDSVPDI	DEG_COP1_1	932:942	Mutation rewiring degron network	0.3056
p.I945T	TCGA-DZ-6133	KIRP	TCGA	DDFDHDSVPDI	DEG_COP1_1	932:942	Mutation rewiring degron network	0.25
p.I945T	DO20762	KIRP	ICGC	DDFDHDSVPDI	DEG_COP1_1	932:942	Mutation rewiring degron network	0.25
p.L1061P	TCGA-IZ-8195	KIRP	TCGA	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.1944
p.L1061P	DO44471	KIRP	ICGC	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.1944
p.D943N	TCGA-QB-AA9O	SKCM	TCGA	DDFDHDSVPDI	DEG_COP1_1	932:942	Mutation rewiring degron network	0.3056
p.D943N	DO51267	SKCM	ICGC	DDFDHDSVPDI	DEG_COP1_1	932:942	Mutation rewiring degron network	0.3056
p.R926Q	TCGA-UC-A7PG	CESC	TCGA	DDFDHDSVPDI	DEG_COP1_1	932:942	Mutation rewiring degron network	0.1667
p.R926Q	DO51615	CESC	ICGC	DDFDHDSVPDI	DEG_COP1_1	932:942	Mutation rewiring degron network	0.1667
p.D944Y	DO229019	LICA	ICGC	DDFDHDSVPDI	DEG_COP1_1	932:942	Mutation rewiring degron network	0.2778
p.G1060S	DO220852	MELA	ICGC	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.1667
p.E1074K	ACH-000687	Lymphoma	CCLE	VNSTT	DEG_SPOP_SBC_1	1066:1070	Mutation rewiring degron network	0.2222

Kaplan plot for THBS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

THBS1

UniProt ID: P07996

Entrez ID: 7057

Protein name: Thrombospondin-1 (Glycoprotein G)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for THBS1 in