DegronMD

Uniprot ID: P07996

Source protein: Thrombospondin-1

Source gene: THBS1

Class: DEG_COP1_1

Location: 932:942

E3 ligase: COP1

DEGRON score: 0.8791

ASA_SCORE: 58.5545

COIL: 0.8762

CONS_SCORE: 0.7012

DSS_SCORE: 0.5202

HELIX: 0.0739

FCONS_SCORE: 0.9832

RIG_SCORE: 0.7226

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D924N	TCGA-A5-A0G9	UCEC	TCGA	DDFDHDSVPDI	DEG_COP1_1	0.1111
p.D924N	DO233120	GACA	ICGC	DDFDHDSVPDI	DEG_COP1_1	0.1111
p.D924N	DO42304	UCEC	ICGC	DDFDHDSVPDI	DEG_COP1_1	0.1111
p.D924N	SIDM00989	Bladder Carcinoma	GDSC	DDFDHDSVPDI	DEG_COP1_1	0.1111
p.D924N	ACH-000802	Bladder Cancer	CCLE	DDFDHDSVPDI	DEG_COP1_1	0.1111
p.D924N	BFTC-905	urinary_tract	COSMIC	DDFDHDSVPDI	DEG_COP1_1	0.1111
p.D943E	TCGA-DX-A8BL	SARC	TCGA	DDFDHDSVPDI	DEG_COP1_1	0.3056
p.D943E	DO220049	SARC	ICGC	DDFDHDSVPDI	DEG_COP1_1	0.3056
p.I945T	TCGA-DZ-6133	KIRP	TCGA	DDFDHDSVPDI	DEG_COP1_1	0.25
p.I945T	DO20762	KIRP	ICGC	DDFDHDSVPDI	DEG_COP1_1	0.25
p.D943N	TCGA-QB-AA9O	SKCM	TCGA	DDFDHDSVPDI	DEG_COP1_1	0.3056
p.D943N	DO51267	SKCM	ICGC	DDFDHDSVPDI	DEG_COP1_1	0.3056
p.R926Q	TCGA-UC-A7PG	CESC	TCGA	DDFDHDSVPDI	DEG_COP1_1	0.1667
p.R926Q	DO51615	CESC	ICGC	DDFDHDSVPDI	DEG_COP1_1	0.1667
p.D944Y	DO229019	LICA	ICGC	DDFDHDSVPDI	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07996	Thrombospondin-1	DEG_COP1_1	932:942	DDFDHDSVPDI	COP1	0.8791	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons