DegronMD - P35442(THBS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T16M	TCGA-3C-AALK	BRCA	TCGA	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1944
p.T16M	TCGA-RW-A68B	PCPG	TCGA	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1944
p.T16M	DO219591	BRCA	ICGC	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1944
p.T16M	SIDM01694	B-Lymphoblastic Leukemia	GDSC	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1944
p.T16M	ACH-000728	Leukemia	CCLE	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1944
p.T1074M	TCGA-AJ-A3BG	UCEC	TCGA	VNSTT	DEG_SPOP_SBC_1	1068:1072	Mutation rewiring degron network	0.2778
p.T1074M	DO42633	UCEC	ICGC	VNSTT	DEG_SPOP_SBC_1	1068:1072	Mutation rewiring degron network	0.2778
p.T1074S	TCGA-AZ-6598	COAD	TCGA	VNSTT	DEG_SPOP_SBC_1	1068:1072	Mutation rewiring degron network	0.2778
p.T1074S	DO10276	COAD	ICGC	VNSTT	DEG_SPOP_SBC_1	1068:1072	Mutation rewiring degron network	0.2778
p.Q17P	TCGA-DD-AAE7	LIHC	TCGA	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1667
p.Q17P	DO52262	LIHC	ICGC	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1667
p.G19S	TCGA-E2-A14N	BRCA	TCGA	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1111
p.G19S	DO2515	BRCA	ICGC	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1111
p.S1061Y	TCGA-FI-A2D5	UCEC	TCGA	VNSTT	DEG_SPOP_SBC_1	1068:1072	Mutation rewiring degron network	0.1389
p.S1061Y	DO41331	UCEC	ICGC	VNSTT	DEG_SPOP_SBC_1	1068:1072	Mutation rewiring degron network	0.1389
p.S1064P	DO228581	GACA	ICGC	VNSTT	DEG_SPOP_SBC_1	1068:1072	Mutation rewiring degron network	0.2222
p.T1071N	DO229022	LICA	ICGC	VNSTT	DEG_SPOP_SBC_1	1068:1072	Mutation altering degron motif	0.7055
p.A1081E	DO229038	LICA	ICGC	VNSTT	DEG_SPOP_SBC_1	1068:1072	Mutation rewiring degron network	0.0833
p.T16K	DO229038	LICA	ICGC	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1944
p.T16K	DO25985	LUAD	ICGC	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1944
p.H20L	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.0833
p.H20L	ACH-000434	Lung Cancer	CCLE	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.0833
p.H20L	NCI-H1915	lung	COSMIC	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.0833
p.Q21K	SIDM01196	Hepatocellular Carcinoma	GDSC	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.0556
p.Q21K	ACH-000422	Liver Cancer	CCLE	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.0556
p.Q21K	SNU-475	liver	COSMIC	WRLVLLALW	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.0556

Kaplan plot for THBS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

THBS2

UniProt ID: P35442

Entrez ID: 7058

Protein name: Thrombospondin-2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for THBS2 in