DegronMD

Uniprot ID: P35442

Source protein: Thrombospondin-2

Source gene: THBS2

Class: DEG_APCC_DBOX_1

Location: 3:11

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8308

ASA_SCORE: 94.8

COIL: 0.2997

CONS_SCORE: 0.3883

DSS_SCORE: 0.0629

HELIX: 0.6217

FCONS_SCORE: 1.2463

RIG_SCORE: 1.0072

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T16M	TCGA-3C-AALK	BRCA	TCGA	WRLVLLALW	DEG_APCC_DBOX_1	0.1944
p.T16M	TCGA-RW-A68B	PCPG	TCGA	WRLVLLALW	DEG_APCC_DBOX_1	0.1944
p.T16M	DO219591	BRCA	ICGC	WRLVLLALW	DEG_APCC_DBOX_1	0.1944
p.T16M	SIDM01694	B-Lymphoblastic Leukemia	GDSC	WRLVLLALW	DEG_APCC_DBOX_1	0.1944
p.T16M	ACH-000728	Leukemia	CCLE	WRLVLLALW	DEG_APCC_DBOX_1	0.1944
p.Q17P	TCGA-DD-AAE7	LIHC	TCGA	WRLVLLALW	DEG_APCC_DBOX_1	0.1667
p.Q17P	DO52262	LIHC	ICGC	WRLVLLALW	DEG_APCC_DBOX_1	0.1667
p.G19S	TCGA-E2-A14N	BRCA	TCGA	WRLVLLALW	DEG_APCC_DBOX_1	0.1111
p.G19S	DO2515	BRCA	ICGC	WRLVLLALW	DEG_APCC_DBOX_1	0.1111
p.T16K	DO229038	LICA	ICGC	WRLVLLALW	DEG_APCC_DBOX_1	0.1944
p.T16K	DO25985	LUAD	ICGC	WRLVLLALW	DEG_APCC_DBOX_1	0.1944
p.H20L	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	WRLVLLALW	DEG_APCC_DBOX_1	0.0833
p.H20L	ACH-000434	Lung Cancer	CCLE	WRLVLLALW	DEG_APCC_DBOX_1	0.0833
p.H20L	NCI-H1915	lung	COSMIC	WRLVLLALW	DEG_APCC_DBOX_1	0.0833
p.Q21K	SIDM01196	Hepatocellular Carcinoma	GDSC	WRLVLLALW	DEG_APCC_DBOX_1	0.0556
p.Q21K	ACH-000422	Liver Cancer	CCLE	WRLVLLALW	DEG_APCC_DBOX_1	0.0556
p.Q21K	SNU-475	liver	COSMIC	WRLVLLALW	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35442	Thrombospondin-2	DEG_APCC_DBOX_1	3:11	WRLVLLALW	APC,CDC20,FZR1	0.8308	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons