DegronMD - Q13190(STX5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K22N	TCGA-BS-A0UV	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	31:35	Mutation substituting flanking lysine	0.1944
p.K22N	DO42793	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	31:35	Mutation substituting flanking lysine	0.1944
p.A230V	TCGA-DF-A2KU	UCEC	TCGA	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation altering degron motif	0.5825
p.A230V	DO223286	UCEC	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation altering degron motif	0.5825
p.G227C	TCGA-EE-A2MG	SKCM	TCGA	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation altering degron motif	0.6489
p.G227C	DO37421	SKCM	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation altering degron motif	0.6489
p.S21P	TCGA-EO-A22R	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	31:35	Mutation blocking phosphorylation signal	0.5
p.S21P	DO42713	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	31:35	Mutation blocking phosphorylation signal	0.5
p.G234V	TCGA-ER-A1A1	SKCM	TCGA	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation rewiring degron network	0.3056
p.G234V	DO37413	SKCM	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation rewiring degron network	0.3056
p.G228D	TCGA-FS-A1ZC	SKCM	TCGA	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation altering degron motif	0.6087
p.G228D	DO37487	SKCM	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation altering degron motif	0.6087
p.L135P	DO225110	BRCA	ICGC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	121:127	Mutation rewiring degron network	0.1111
p.E134D	DO225150	BRCA	ICGC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	121:127	Mutation rewiring degron network	0.1389
p.H225Q	DO9940	COAD	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation altering degron motif	0.647
p.R121C	DO222765	COCA	ICGC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	121:127	Mutation altering degron motif	0.8301
p.S240Y	DO50327	ESAD	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation rewiring degron network	0.1389
p.R213W	DO218136	GACA	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation rewiring degron network	0.1111
p.L124I	DO233652	GACA	ICGC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	121:127	Mutation altering degron motif	0.6063
p.S36N	DO52671	MALY	ICGC	AGSSS	DEG_SPOP_SBC_1	31:35	Mutation rewiring degron network	0.3056
p.S212F	DO220886	MELA	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation rewiring degron network	0.0833
p.A230D	DO232761	PBCA	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation altering degron motif	0.6682
p.P44Q	DO229234	THCA	ICGC	AGSSS	DEG_SPOP_SBC_1	31:35	Mutation rewiring degron network	0.0833
p.A235V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation rewiring degron network	0.2778
p.A235V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation rewiring degron network	0.2778
p.A235V	ACH-000995	Leukemia	CCLE	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation rewiring degron network	0.2778
p.A235V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation rewiring degron network	0.2778
p.A218V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation rewiring degron network	0.25
p.A218V	ACH-000920	Leukemia	CCLE	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation rewiring degron network	0.25
p.A218V	CML-T1	haematopoietic and lymphoid tissue	COSMIC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation rewiring degron network	0.25
p.D37V	SIDM01165	Pancreatic Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	31:35	Mutation rewiring degron network	0.2778
p.D37V	ACH-000155	Pancreatic Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	31:35	Mutation rewiring degron network	0.2778
p.L112M	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	121:127	Mutation rewiring degron network	0.0833
p.L112M	ACH-000442	Lung Cancer	CCLE	RKSLFDD	LIG_APCC_ABBAyCdc20_2	121:127	Mutation rewiring degron network	0.0833
p.L112M	RERF-LC-Sq1	lung	COSMIC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	121:127	Mutation rewiring degron network	0.0833
p.L115P	SIDM00213	Thyroid Gland Carcinoma	GDSC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	121:127	Mutation rewiring degron network	0.1667
p.L115P	ACH-000903	Thyroid Cancer	CCLE	RKSLFDD	LIG_APCC_ABBAyCdc20_2	121:127	Mutation rewiring degron network	0.1667
p.L115P	FTC-133	thyroid	COSMIC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	121:127	Mutation rewiring degron network	0.1667
p.A214V	ACH-001841	Bile Duct Cancer	CCLE	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation rewiring degron network	0.1389
p.N119H	IM-9	haematopoietic and lymphoid tissue	COSMIC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	121:127	Mutation rewiring degron network	0.2778
p.R32C	NCI-H716	large intestine	COSMIC	AGSSS	DEG_SPOP_SBC_1	31:35	Mutation altering degron motif	0.8301
p.R215W	MZ2-MEL	skin	COSMIC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	221:233	Mutation rewiring degron network	0.1667

Kaplan plot for STX5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STX5

UniProt ID: Q13190

Entrez ID: 6811

Protein name: Syntaxin-5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STX5 in