DegronMD

Uniprot ID: Q13190

Source protein: Syntaxin-5

Source gene: STX5

Class: DEG_ODPH_VHL_1

Location: 221:233

E3 ligase: VHL

DEGRON score: 0.8488

ASA_SCORE: 66.8308

COIL: 0.7877

CONS_SCORE: 0.31

DSS_SCORE: 0.3835

HELIX: 0.1456

FCONS_SCORE: 0.9666

RIG_SCORE: 0.6657

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A230V	TCGA-DF-A2KU	UCEC	TCGA	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.5825
p.A230V	DO223286	UCEC	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.5825
p.G227C	TCGA-EE-A2MG	SKCM	TCGA	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.6489
p.G227C	DO37421	SKCM	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.6489
p.G234V	TCGA-ER-A1A1	SKCM	TCGA	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.3056
p.G234V	DO37413	SKCM	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.3056
p.G228D	TCGA-FS-A1ZC	SKCM	TCGA	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.6087
p.G228D	DO37487	SKCM	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.6087
p.H225Q	DO9940	COAD	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.647
p.S240Y	DO50327	ESAD	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.1389
p.R213W	DO218136	GACA	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.1111
p.S212F	DO220886	MELA	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.0833
p.A230D	DO232761	PBCA	ICGC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.6682
p.A235V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.2778
p.A235V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.2778
p.A235V	ACH-000995	Leukemia	CCLE	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.2778
p.A235V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.2778
p.A218V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.25
p.A218V	ACH-000920	Leukemia	CCLE	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.25
p.A218V	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.25
p.A214V	ACH-001841	Bile Duct Cancer	CCLE	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.1389
p.R215W	MZ2-MEL	skin	COSMIC	LAPNHLGGGAVVL	DEG_ODPH_VHL_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13190	Syntaxin-5	DEG_ODPH_VHL_1	221:233	LAPNHLGGGAVVL	VHL	0.8488	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons