DegronMD

Uniprot ID: Q13190

Source protein: Syntaxin-5

Source gene: STX5

Class: LIG_APCC_ABBAyCdc20_2

Location: 121:127

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6548

ASA_SCORE: 96.7714

COIL: 0.7427

CONS_SCORE: 0.6334

DSS_SCORE: 0.0559

HELIX: 0.2403

FCONS_SCORE: 1.0501

RIG_SCORE: 0.857

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L135P	DO225110	BRCA	ICGC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E134D	DO225150	BRCA	ICGC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R121C	DO222765	COCA	ICGC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	0.8301
p.L124I	DO233652	GACA	ICGC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	0.6063
p.L112M	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	0.0833
p.L112M	ACH-000442	Lung Cancer	CCLE	RKSLFDD	LIG_APCC_ABBAyCdc20_2	0.0833
p.L112M	RERF-LC-Sq1	lung	COSMIC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	0.0833
p.L115P	SIDM00213	Thyroid Gland Carcinoma	GDSC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.L115P	ACH-000903	Thyroid Cancer	CCLE	RKSLFDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.L115P	FTC-133	thyroid	COSMIC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.N119H	IM-9	haematopoietic_and_lymphoid_tissue	COSMIC	RKSLFDD	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13190	Syntaxin-5	LIG_APCC_ABBAyCdc20_2	121:127	RKSLFDD	APC,CDC20,FZR1	0.6548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons