DegronMD - Q96JM4(LRRIQ1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W1495C	TCGA-17-Z045	LUAD	TCGA	DKENL	DEG_APCC_KENBOX_2	1499:1503	Mutation rewiring degron network	0.2222
p.H1707Q	TCGA-2W-A8YY	CESC	TCGA	AGSSS	DEG_SPOP_SBC_1	1709:1713	Mutation rewiring degron network	0.2778
p.H1707Q	DO223732	CESC	ICGC	AGSSS	DEG_SPOP_SBC_1	1709:1713	Mutation rewiring degron network	0.2778
p.Q1510K	TCGA-32-2491	GBM	TCGA	DKENL	DEG_APCC_KENBOX_2	1499:1503	Mutation rewiring degron network	0.1389
p.Q1510K	DO13354	GBM	ICGC	DKENL	DEG_APCC_KENBOX_2	1499:1503	Mutation rewiring degron network	0.1389
p.L1721S	TCGA-AJ-A3EL	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	1709:1713	Mutation rewiring degron network	0.1111
p.L1721S	DO41542	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	1709:1713	Mutation rewiring degron network	0.1111
p.E137K	TCGA-AO-A03M	BRCA	TCGA	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation altering degron motif	0.7022
p.E137K	DO2216	BRCA	ICGC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation altering degron motif	0.7022
p.T1509I	TCGA-AX-A1CE	UCEC	TCGA	DKENL	DEG_APCC_KENBOX_2	1499:1503	Mutation rewiring degron network	0.1667
p.T1509I	DO42280	UCEC	ICGC	DKENL	DEG_APCC_KENBOX_2	1499:1503	Mutation rewiring degron network	0.1667
p.K1714R	TCGA-B5-A3FA	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	1709:1713	Mutation rewiring degron network	0.3056
p.K1714R	DO52402	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	1709:1713	Mutation rewiring degron network	0.3056
p.P140H	TCGA-CA-5254	COAD	TCGA	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.2778
p.P140H	DO8674	COAD	ICGC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.2778
p.P140H	ACH-002287	Colon/Colorectal Cancer	CCLE	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.2778
p.P140H	NCI-H630	large intestine	COSMIC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.2778
p.K126E	TCGA-CG-5721	STAD	TCGA	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.3056
p.K126E	DO38192	STAD	ICGC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.3056
p.S1489C	TCGA-DK-AA71	BLCA	TCGA	DKENL	DEG_APCC_KENBOX_2	1499:1503	Mutation rewiring degron network	0.0556
p.S1489C	DO219010	BLCA	ICGC	DKENL	DEG_APCC_KENBOX_2	1499:1503	Mutation rewiring degron network	0.0556
p.K1701N	TCGA-DU-6407	LGG	TCGA	AGSSS	DEG_SPOP_SBC_1	1709:1713	Mutation substituting flanking lysine	0.2222
p.K1701N	DO22295	LGG	ICGC	AGSSS	DEG_SPOP_SBC_1	1709:1713	Mutation substituting flanking lysine	0.2222
p.E121K	TCGA-FR-A729	SKCM	TCGA	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.1667
p.E121K	DO48618	SKCM	ICGC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.1667
p.M145V	TCGA-G2-A2EL	BLCA	TCGA	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.1389
p.M145V	DO478	BLCA	ICGC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.1389
p.E118Q	TCGA-KQ-A41R	BLCA	TCGA	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.0833
p.E118Q	DO223592	BLCA	ICGC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.0833
p.E118Q	DO224565	BRCA	ICGC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.0833
p.E118Q	DO1004	BRCA	ICGC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.0833
p.K126T	TCGA-ND-A4WC	UCS	TCGA	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.3056
p.D128H	DO217931	BRCA	ICGC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation altering degron motif	0.7688
p.P138A	DO222445	BTCA	ICGC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation altering degron motif	0.6392
p.M123R	DO234179	ESAD	ICGC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.2222
p.E120G	DO229346	LAML	ICGC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.1389
p.E120G	SIDM00531	Pancreatic Carcinoma	GDSC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.1389
p.E120G	HuP-T4	pancreas	COSMIC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.1389
p.H148Q	DO231974	LICA	ICGC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.0556
p.P144T	DO228821	LICA	ICGC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.1667
p.C1497F	DO229036	LICA	ICGC	DKENL	DEG_APCC_KENBOX_2	1499:1503	Mutation rewiring degron network	0.2778
p.D1499N	DO221126	MALY	ICGC	DKENL	DEG_APCC_KENBOX_2	1499:1503	Mutation altering degron motif	0.5821
p.D146N	DO220879	MELA	ICGC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.1111
p.M123I	DO232044	ORCA	ICGC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.2222
p.F122L	SIDM02027	Colorectal Carcinoma	GDSC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.1944
p.S125R	SIDM02027	Colorectal Carcinoma	GDSC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.2778
p.E1699G	SIDM00072	Non-Cancerous	GDSC	AGSSS	DEG_SPOP_SBC_1	1709:1713	Mutation rewiring degron network	0.0556
p.E1699G	SIDM00858	Osteosarcoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1709:1713	Mutation rewiring degron network	0.0556
p.E1699G	SIDM00150	Colorectal Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1709:1713	Mutation rewiring degron network	0.0556
p.E1699G	SIDM00760	Small Cell Lung Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1709:1713	Mutation rewiring degron network	0.0556
p.E1699G	SIDM01445	Gastric Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1709:1713	Mutation rewiring degron network	0.0556
p.L1503V	SIDM01218	Other Solid Cancers	GDSC	DKENL	DEG_APCC_KENBOX_2	1499:1503	Mutation altering degron motif	0.5654
p.L1503V	ACH-001530	Endometrial/Uterine Cancer	CCLE	DKENL	DEG_APCC_KENBOX_2	1499:1503	Mutation altering degron motif	0.5654
p.L1503V	JEG-3	placenta	COSMIC	DKENL	DEG_APCC_KENBOX_2	1499:1503	Mutation altering degron motif	0.5654
p.H148R	SIDM00238	Ovarian Carcinoma	GDSC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.0556
p.H148R	ACH-000947	Ovarian Cancer	CCLE	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.0556
p.H148R	OVK-18	ovary	COSMIC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.0556
p.S139C	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.3056
p.S139C	H513	pleura	COSMIC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.3056
p.D146Y	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.1111
p.D146Y	ACH-001489	Lung Cancer	CCLE	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.1111
p.D146Y	COR-L32	lung	COSMIC	TDCATPDFVPEP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.1111
p.P1718L	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1709:1713	Mutation rewiring degron network	0.1944
p.P1718L	ACH-000851	Lung Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	1709:1713	Mutation rewiring degron network	0.1944
p.G1710R	ACH-002021	Endometrial/Uterine Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	1709:1713	Mutation altering degron motif	0.6457

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRIQ1

UniProt ID: Q96JM4

Entrez ID: 84125

Protein name: Leucine-rich repeat and IQ domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRIQ1 in