DegronMD

Uniprot ID: Q96JM4

Source protein: Leucine-rich repeat and IQ domain-containing protein 1

Source gene: LRRIQ1

Class: DEG_APCC_KENBOX_2

Location: 1499:1503

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9715

ASA_SCORE: 103.48

COIL: 0.8018

CONS_SCORE: 0.584

DSS_SCORE: 0.511

HELIX: 0.1768

FCONS_SCORE: 0.9494

RIG_SCORE: 0.709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W1495C	TCGA-17-Z045	LUAD	TCGA	DKENL	DEG_APCC_KENBOX_2	0.2222
p.Q1510K	TCGA-32-2491	GBM	TCGA	DKENL	DEG_APCC_KENBOX_2	0.1389
p.Q1510K	DO13354	GBM	ICGC	DKENL	DEG_APCC_KENBOX_2	0.1389
p.T1509I	TCGA-AX-A1CE	UCEC	TCGA	DKENL	DEG_APCC_KENBOX_2	0.1667
p.T1509I	DO42280	UCEC	ICGC	DKENL	DEG_APCC_KENBOX_2	0.1667
p.S1489C	TCGA-DK-AA71	BLCA	TCGA	DKENL	DEG_APCC_KENBOX_2	0.0556
p.S1489C	DO219010	BLCA	ICGC	DKENL	DEG_APCC_KENBOX_2	0.0556
p.C1497F	DO229036	LICA	ICGC	DKENL	DEG_APCC_KENBOX_2	0.2778
p.D1499N	DO221126	MALY	ICGC	DKENL	DEG_APCC_KENBOX_2	0.5821
p.L1503V	SIDM01218	Other Solid Cancers	GDSC	DKENL	DEG_APCC_KENBOX_2	0.5654
p.L1503V	ACH-001530	Endometrial/Uterine Cancer	CCLE	DKENL	DEG_APCC_KENBOX_2	0.5654
p.L1503V	JEG-3	placenta	COSMIC	DKENL	DEG_APCC_KENBOX_2	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17022	Zinc finger protein 18	DEG_APCC_KENBOX_2	294:298	DKENL	APC,CDC20,FZR1	0.9976	More...
Q5MIZ7	Serine/threonine-protein phosphatase 4 regulatory subunit 3B	DEG_APCC_KENBOX_2	759:763	DKENL	APC,CDC20,FZR1	0.996	More...
Q9BZI7	Regulator of nonsense transcripts 3B	DEG_APCC_KENBOX_2	305:309	DKENL	APC,CDC20,FZR1	0.9885	More...
Q96JM4	Leucine-rich repeat and IQ domain-containing protein 1	DEG_APCC_KENBOX_2	1499:1503	DKENL	APC,CDC20,FZR1	0.9715	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons