DegronMD

Uniprot ID: P17022

Source protein: Zinc finger protein 18

Source gene: ZNF18

Class: DEG_APCC_KENBOX_2

Location: 294:298

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9976

ASA_SCORE: 118.66

COIL: 0.7244

CONS_SCORE: 0.9811

DSS_SCORE: 0.5699

HELIX: 0.23

FCONS_SCORE: 1.2815

RIG_SCORE: 0.7251

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D289N	TCGA-A5-A0G2	UCEC	TCGA	DKENL	DEG_APCC_KENBOX_2	0.1944
p.D289N	DO41235	UCEC	ICGC	DKENL	DEG_APCC_KENBOX_2	0.1944
p.E296D	TCGA-A5-A2K5	UCEC	TCGA	DKENL	DEG_APCC_KENBOX_2	0.6758
p.E296D	TCGA-AA-3977	COAD	TCGA	DKENL	DEG_APCC_KENBOX_2	0.6758
p.E296D	TCGA-BS-A0UF	UCEC	TCGA	DKENL	DEG_APCC_KENBOX_2	0.6758
p.E296D	DO8898	COAD	ICGC	DKENL	DEG_APCC_KENBOX_2	0.6758
p.E296D	DO8730	COAD	ICGC	DKENL	DEG_APCC_KENBOX_2	0.6758
p.E296D	DO41488	UCEC	ICGC	DKENL	DEG_APCC_KENBOX_2	0.6758
p.E296D	DO41379	UCEC	ICGC	DKENL	DEG_APCC_KENBOX_2	0.6758
p.P284H	TCGA-D3-A3C8	SKCM	TCGA	DKENL	DEG_APCC_KENBOX_2	0.0556
p.P284H	DO47636	SKCM	ICGC	DKENL	DEG_APCC_KENBOX_2	0.0556
p.E292D	DO50875	LICA	ICGC	DKENL	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17022	Zinc finger protein 18	DEG_APCC_KENBOX_2	294:298	DKENL	APC,CDC20,FZR1	0.9976	More...
Q5MIZ7	Serine/threonine-protein phosphatase 4 regulatory subunit 3B	DEG_APCC_KENBOX_2	759:763	DKENL	APC,CDC20,FZR1	0.996	More...
Q9BZI7	Regulator of nonsense transcripts 3B	DEG_APCC_KENBOX_2	305:309	DKENL	APC,CDC20,FZR1	0.9885	More...
Q96JM4	Leucine-rich repeat and IQ domain-containing protein 1	DEG_APCC_KENBOX_2	1499:1503	DKENL	APC,CDC20,FZR1	0.9715	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons