DegronMD - Q9BZI7(UPF3B)

UPF3B

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E299D	TCGA-97-7938	LUAD	TCGA	DKENL	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.1667
p.K302N	TCGA-A5-A0G1	UCEC	TCGA	DKENL	DEG_APCC_KENBOX_2	305:309	Mutation substituting flanking lysine	0.3611
p.R298K	TCGA-AG-A00Y	READ	TCGA	DKENL	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.1389
p.K297Q	TCGA-B5-A11G	UCEC	TCGA	DKENL	DEG_APCC_KENBOX_2	305:309	Mutation substituting flanking lysine	0.2222
p.K303E	TCGA-BR-4361	STAD	TCGA	DKENL	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.2778
p.L309F	TCGA-CV-A465	HNSC	TCGA	DKENL	DEG_APCC_KENBOX_2	305:309	Mutation altering degron motif	0.587
p.E319K	DO2401	BRCA	ICGC	DKENL	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.0556
p.L296F	DO52069	HNSC	ICGC	DKENL	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.0833
p.S314N	DO23184	LINC	ICGC	DKENL	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.1944
p.K310E	DO42673	UCEC	ICGC	DKENL	DEG_APCC_KENBOX_2	305:309	Mutation blocking phosphorylation signal	0.75
p.A301T	SIDM01175	Other Sarcomas	GDSC	DKENL	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.2222
p.A301T	SW684	soft tissue	COSMIC	DKENL	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc