DegronMD

Uniprot ID: Q9BZI7

Source protein: Regulator of nonsense transcripts 3B

Source gene: UPF3B

Class: DEG_APCC_KENBOX_2

Location: 305:309

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9885

ASA_SCORE: 113.4

COIL: 0.4358

CONS_SCORE: 0.4528

DSS_SCORE: 0.6242

HELIX: 0.5646

FCONS_SCORE: 1.2426

RIG_SCORE: 0.6799

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E299D	TCGA-97-7938	LUAD	TCGA	DKENL	DEG_APCC_KENBOX_2	0.1667
p.K302N	TCGA-A5-A0G1	UCEC	TCGA	DKENL	DEG_APCC_KENBOX_2	0.3611
p.R298K	TCGA-AG-A00Y	READ	TCGA	DKENL	DEG_APCC_KENBOX_2	0.1389
p.K297Q	TCGA-B5-A11G	UCEC	TCGA	DKENL	DEG_APCC_KENBOX_2	0.2222
p.K303E	TCGA-BR-4361	STAD	TCGA	DKENL	DEG_APCC_KENBOX_2	0.2778
p.L309F	TCGA-CV-A465	HNSC	TCGA	DKENL	DEG_APCC_KENBOX_2	0.587
p.E319K	DO2401	BRCA	ICGC	DKENL	DEG_APCC_KENBOX_2	0.0556
p.L296F	DO52069	HNSC	ICGC	DKENL	DEG_APCC_KENBOX_2	0.0833
p.S314N	DO23184	LINC	ICGC	DKENL	DEG_APCC_KENBOX_2	0.1944
p.K310E	DO42673	UCEC	ICGC	DKENL	DEG_APCC_KENBOX_2	0.75
p.A301T	SIDM01175	Other Sarcomas	GDSC	DKENL	DEG_APCC_KENBOX_2	0.2222
p.A301T	SW684	soft_tissue	COSMIC	DKENL	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17022	Zinc finger protein 18	DEG_APCC_KENBOX_2	294:298	DKENL	APC,CDC20,FZR1	0.9976	More...
Q5MIZ7	Serine/threonine-protein phosphatase 4 regulatory subunit 3B	DEG_APCC_KENBOX_2	759:763	DKENL	APC,CDC20,FZR1	0.996	More...
Q9BZI7	Regulator of nonsense transcripts 3B	DEG_APCC_KENBOX_2	305:309	DKENL	APC,CDC20,FZR1	0.9885	More...
Q96JM4	Leucine-rich repeat and IQ domain-containing protein 1	DEG_APCC_KENBOX_2	1499:1503	DKENL	APC,CDC20,FZR1	0.9715	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons