DegronMD

Uniprot ID: Q5MIZ7

Source protein: Serine/threonine-protein phosphatase 4 regulatory subunit 3B

Source gene: PPP4R3B

Class: DEG_APCC_KENBOX_2

Location: 759:763

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.996

ASA_SCORE: 105.2

COIL: 0.7202

CONS_SCORE: 0.2744

DSS_SCORE: 0.6669

HELIX: 0.2748

FCONS_SCORE: 1.1516

RIG_SCORE: 0.6842

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T767S	SIDM01612	Endometrial Carcinoma	GDSC	DKENL	DEG_APCC_KENBOX_2	0.2222
p.N762Y	SIDM01435	Hepatocellular Carcinoma	GDSC	DKENL	DEG_APCC_KENBOX_2	0.7059
p.R761L	CAL-78	bone	COSMIC	DKENL	DEG_APCC_KENBOX_2	0.8428
p.S768F	CW-2	large_intestine	COSMIC	DKENL	DEG_APCC_KENBOX_2	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17022	Zinc finger protein 18	DEG_APCC_KENBOX_2	294:298	DKENL	APC,CDC20,FZR1	0.9976	More...
Q5MIZ7	Serine/threonine-protein phosphatase 4 regulatory subunit 3B	DEG_APCC_KENBOX_2	759:763	DKENL	APC,CDC20,FZR1	0.996	More...
Q9BZI7	Regulator of nonsense transcripts 3B	DEG_APCC_KENBOX_2	305:309	DKENL	APC,CDC20,FZR1	0.9885	More...
Q96JM4	Leucine-rich repeat and IQ domain-containing protein 1	DEG_APCC_KENBOX_2	1499:1503	DKENL	APC,CDC20,FZR1	0.9715	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons