DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
DKENL
Uniprot ID:
Q5MIZ7
Source protein:
Serine/threonine-protein phosphatase 4 regulatory subunit 3B
Source gene:
PPP4R3B
Class:
DEG_APCC_KENBOX_2
Location:
759:763
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.996
ASA_SCORE:
105.2
COIL:
0.7202
CONS_SCORE:
0.2744
DSS_SCORE:
0.6669
HELIX:
0.2748
FCONS_SCORE:
1.1516
RIG_SCORE:
0.6842
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R761L
CAL-78
bone
COSMIC
DKENL
DEG_APCC_KENBOX_2
0.8428
p.N762Y
SIDM01435
Hepatocellular Carcinoma
GDSC
DKENL
DEG_APCC_KENBOX_2
0.7059
p.S768F
CW-2
large_intestine
COSMIC
DKENL
DEG_APCC_KENBOX_2
0.6389
p.T767S
SIDM01612
Endometrial Carcinoma
GDSC
DKENL
DEG_APCC_KENBOX_2
0.2222
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Drug responses associated with PPP4R3B mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of DKENL
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96JM4
Leucine-rich repeat and IQ domain-containing protein 1
DEG_APCC_KENBOX_2
1499:1503
DKENL
APC,CDC20,FZR1
0.9715
More...
Q9BZI7
Regulator of nonsense transcripts 3B
DEG_APCC_KENBOX_2
305:309
DKENL
APC,CDC20,FZR1
0.9885
More...
Q5MIZ7
Serine/threonine-protein phosphatase 4 regulatory subunit 3B
DEG_APCC_KENBOX_2
759:763
DKENL
APC,CDC20,FZR1
0.996
More...
P17022
Zinc finger protein 18
DEG_APCC_KENBOX_2
294:298
DKENL
APC,CDC20,FZR1
0.9976
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