DegronMD

Uniprot ID: Q96JM4

Source protein: Leucine-rich repeat and IQ domain-containing protein 1

Source gene: LRRIQ1

Class: DEG_COP1_1

Location: 127:138

E3 ligase: COP1

DEGRON score: 0.7674

ASA_SCORE: 97.6

COIL: 0.9013

CONS_SCORE: 0.6176

DSS_SCORE: 0.6213

HELIX: 0.0654

FCONS_SCORE: 0.9463

RIG_SCORE: 0.6801

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E137K	TCGA-AO-A03M	BRCA	TCGA	TDCATPDFVPEP	DEG_COP1_1	0.7022
p.E137K	DO2216	BRCA	ICGC	TDCATPDFVPEP	DEG_COP1_1	0.7022
p.P140H	TCGA-CA-5254	COAD	TCGA	TDCATPDFVPEP	DEG_COP1_1	0.2778
p.P140H	DO8674	COAD	ICGC	TDCATPDFVPEP	DEG_COP1_1	0.2778
p.P140H	ACH-002287	Colon/Colorectal Cancer	CCLE	TDCATPDFVPEP	DEG_COP1_1	0.2778
p.P140H	NCI-H630	large_intestine	COSMIC	TDCATPDFVPEP	DEG_COP1_1	0.2778
p.K126E	TCGA-CG-5721	STAD	TCGA	TDCATPDFVPEP	DEG_COP1_1	0.3056
p.K126E	DO38192	STAD	ICGC	TDCATPDFVPEP	DEG_COP1_1	0.3056
p.E121K	TCGA-FR-A729	SKCM	TCGA	TDCATPDFVPEP	DEG_COP1_1	0.1667
p.E121K	DO48618	SKCM	ICGC	TDCATPDFVPEP	DEG_COP1_1	0.1667
p.M145V	TCGA-G2-A2EL	BLCA	TCGA	TDCATPDFVPEP	DEG_COP1_1	0.1389
p.M145V	DO478	BLCA	ICGC	TDCATPDFVPEP	DEG_COP1_1	0.1389
p.E118Q	TCGA-KQ-A41R	BLCA	TCGA	TDCATPDFVPEP	DEG_COP1_1	0.0833
p.E118Q	DO223592	BLCA	ICGC	TDCATPDFVPEP	DEG_COP1_1	0.0833
p.E118Q	DO224565	BRCA	ICGC	TDCATPDFVPEP	DEG_COP1_1	0.0833
p.E118Q	DO1004	BRCA	ICGC	TDCATPDFVPEP	DEG_COP1_1	0.0833
p.K126T	TCGA-ND-A4WC	UCS	TCGA	TDCATPDFVPEP	DEG_COP1_1	0.3056
p.D128H	DO217931	BRCA	ICGC	TDCATPDFVPEP	DEG_COP1_1	0.7688
p.P138A	DO222445	BTCA	ICGC	TDCATPDFVPEP	DEG_COP1_1	0.6392
p.M123R	DO234179	ESAD	ICGC	TDCATPDFVPEP	DEG_COP1_1	0.2222
p.E120G	DO229346	LAML	ICGC	TDCATPDFVPEP	DEG_COP1_1	0.1389
p.E120G	SIDM00531	Pancreatic Carcinoma	GDSC	TDCATPDFVPEP	DEG_COP1_1	0.1389
p.E120G	HuP-T4	pancreas	COSMIC	TDCATPDFVPEP	DEG_COP1_1	0.1389
p.H148Q	DO231974	LICA	ICGC	TDCATPDFVPEP	DEG_COP1_1	0.0556
p.P144T	DO228821	LICA	ICGC	TDCATPDFVPEP	DEG_COP1_1	0.1667
p.D146N	DO220879	MELA	ICGC	TDCATPDFVPEP	DEG_COP1_1	0.1111
p.M123I	DO232044	ORCA	ICGC	TDCATPDFVPEP	DEG_COP1_1	0.2222
p.F122L	SIDM02027	Colorectal Carcinoma	GDSC	TDCATPDFVPEP	DEG_COP1_1	0.1944
p.S125R	SIDM02027	Colorectal Carcinoma	GDSC	TDCATPDFVPEP	DEG_COP1_1	0.2778
p.H148R	SIDM00238	Ovarian Carcinoma	GDSC	TDCATPDFVPEP	DEG_COP1_1	0.0556
p.H148R	ACH-000947	Ovarian Cancer	CCLE	TDCATPDFVPEP	DEG_COP1_1	0.0556
p.H148R	OVK-18	ovary	COSMIC	TDCATPDFVPEP	DEG_COP1_1	0.0556
p.S139C	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	TDCATPDFVPEP	DEG_COP1_1	0.3056
p.S139C	H513	pleura	COSMIC	TDCATPDFVPEP	DEG_COP1_1	0.3056
p.D146Y	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	TDCATPDFVPEP	DEG_COP1_1	0.1111
p.D146Y	ACH-001489	Lung Cancer	CCLE	TDCATPDFVPEP	DEG_COP1_1	0.1111
p.D146Y	COR-L32	lung	COSMIC	TDCATPDFVPEP	DEG_COP1_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TDCATPDFVPEP

Degron related mutations and impact score

Drug responses associated with LRRIQ1 mutations

All proteins holding degron of TDCATPDFVPEP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JM4	Leucine-rich repeat and IQ domain-containing protein 1	DEG_COP1_1	127:138	TDCATPDFVPEP	COP1	0.7674	More...