DegronMD - A8MVX0(ARHGEF33)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T193S	TCGA-AA-3492	COAD	TCGA	PTTPEAE	DEG_SCF_FBW7_2	192:198	Mutation altering degron motif	0.6005
p.T193S	DO8224	COAD	ICGC	PTTPEAE	DEG_SCF_FBW7_2	192:198	Mutation altering degron motif	0.6005
p.L205I	TCGA-L5-A8NM	ESCA	TCGA	PTTPEAE	DEG_SCF_FBW7_2	192:198	Mutation rewiring degron network	0.1389
p.P192T	DO233941	GACA	ICGC	PTTPEAE	DEG_SCF_FBW7_2	192:198	Mutation altering degron motif	0.7031
p.E198A	DO26971	LUSC	ICGC	PTTPEAE	DEG_SCF_FBW7_2	192:198	Mutation altering degron motif	0.7701
p.A694V	DO233297	NACA	ICGC	AGSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1667
p.E693K	DO218896	SKCA	ICGC	AGSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1944
p.A695E	DO229229	THCA	ICGC	AGSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1389
p.A694E	SIDM02015	Colorectal Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1667
p.S679C	ACH-001838	Bile Duct Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons